1 - Introductory Pharmacology

Question 1

define pharmacodynamics

Answer 1

Pharmacodynamics

what a drug does to the body (biological effects and mechanism of action)

Question 2

define pharmacokinetics

Answer 2

what the body does to a drug (abosrption, distribution, metabolism and excretion of drugs and their metabolites)

Question 3

agonists possess _____ and _____

Answer 3

affinity and efficacy

Question 4

define affinity

Answer 4

the strength of association between ligand and receptor

Question 5

define efficacy

Answer 5

the ability of an agonist to evoke a cellular response

Question 6

antagonist possess___ but lack ____

Answer 6

affinity , efficacy

Question 7

what is EC50

Answer 7

the concentration of agonist that elicits a half maximal response

Question 8

in a linear plot the relationship between concentration of agonist and response is _____

Answer 8

hyperbolic

Question 9

in a semi-logarithmic plot the relationship between concentration of agonist and response is _____

Answer 9

sigmoidal

Question 10

what happens to the curve on a semi-logarithmic plot if a competitive agonist is added ?

Answer 10

shifted to the left parrallel

no change in maximal response

Question 11

what happens to the curve on a semi-logarithmic plot if a non- competitive agonist is added ?

Answer 11

not shifted to the left but maximum response not reached