1 Introduction To Protein Structure Flashcards
Q: What is the simplest amino acid? What is it’s R group?
A: Glycine. H
Q: Name 4 amino acids with polar side chains.
A: Serine (OH), threonine (OH), Tyrosine (OH), asparagine (CONH2), cysteine (SH)
Q: Are amino acids with polar side chains hydrophilic or hydrophobic?
A: Hydrophilic
Q: Which polar amino acid has a 6 carbon ring?
A: Tyrosine
Q: Name 3 amino acids with positively charged side chains.
A: lysine (NH3+), arginine (NH2NH2 +), histidine (NH in ring)
Q: If an amino acid has a positively charged side chain, is it acidic or basic?
A: basic
Q: Name 2 amino acids with negatively charged side chains.
A: aspartate and glutamate (COO-)
Q: If an amino acid has a negatively charged side chain, is it acidic or basic?
A: Acidic
Q: What travels further during electrophoresis, HbS or HbA?
A: HbA as it is more negatively charged (HbA has lost negatively charged glutamate)
Q: What do hydrogen bonds form between?
A: CO and NH
Q: What is a peptide bond?
A: C=O
I
H- N
Q: What form are amino acids found in proteins?
A: L
Q: What is there no free rotation round?
A: peptide bond
Q: What causes a kink in an alpha helix peptide chain?
A: Proline, NH is lost when it joins and therefore it can’t form a H bond with CO with another part of helix
Q: How does warfarin work?
A: prevents carboxylation reaction which is vital in blood clotting cascade of glutamate (post translational mod)
