1. Intro and Laterality Flashcards

1
Q

What is variation?

A

Abnormal in structure but not due to disease or trauma

Anatomical variation is a term used to describe any variant of the normal, expected anatomical presentation (Georgiev 2017).

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2
Q

Which paper looked at variations in surface anatomy?

A

Mirjalilli et al 2012

E.g. coeliac trunk at T12

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3
Q

What is the link between infants with minor and major abnormalities? Which paper looked at this?

A

Infants with >/3 minor abnormalities have 20% chance of major abnormalities

Sanudo et al 2003

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4
Q

What is situs solitus?

A

Normal position of thoracic and abdominal organs

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5
Q

What is situs inversus?

A

Major visceral organs are reversed from their normal positions

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6
Q

What is situs ambiguous?

A

Asymmetry of unpaired organs (heart, liver) - reversed association along L/R axis

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7
Q

Which tends to cause more symptoms - SI or SA?

A

SA (SI usually works, SA has more functional problems)

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8
Q

What is isomerism?

A

Asymmetry of paired organs

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9
Q

What is step 1 of L/R axis formation?

A

Break the global embryological symmetry and create centre of information (things usually pushed to left by cilia)

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10
Q

What is step 2 of L/R axis formation?

A

L/R information is propagated and spread to the lateral plate mesoderm
Asymmetric expression of genes in the left lateral plate mesoderm - depends on intact midline

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11
Q

What is step 3 of L/R axis formation?

A

Recognition by primordia and asymmetric morphogenesis
Unpaired organs - displace from midline or unilateral regression of a bilateral pair
Paired organs - direct translation of L/R signal

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12
Q

What paper highlighted the importance of scanning in SI patients?

A

Blegen 1949

45% error in diagnosis of SI patients

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13
Q

What did Fulcher and Turner (2002) investigate?

A

Patient with SI and lymphoma - mistakenly thought large node to right of aorta was IVC
IVC was actually on the left

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14
Q

What did Fang et al (2009) investigate?

A

Pacemaker insertion in patient with detrocardia and SIT
Apex on right of body
Challenging to place atrial and ventricular leads

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