1 Intro and Electrophysiology Flashcards

1
Q

What is the pericardial sac?

A

The tough fibrous sac that encloses the heart

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2
Q

What are the layers of the pericardial sac?

A

Parietal pericardium (outer)

Visceral pericardium (inner)

Pericardial fluid in between, lubricating the two layers

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3
Q

What are the three layers of the heart wall?

A

Epicardium - thin serous membrane on outer aspect of the heart

Myocardium - the muscular middle layer

Endocardium - thin serous membrane lining the inner chambers and valves

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4
Q

What are the two basic cell types in the heart?

A

Myocardial cells - have contractile ability

Conducting cells - pacemaker cells and electrical conducting cells

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5
Q

Describe the myocardial cells

A

“Working cells” of the heart

Consist of latticework of protein filaments (myosin and actin)

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6
Q

The branching network of myocardial cells in the heart is called…

A

A syncytium

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7
Q

Cardiomyocytes are ________ cells with a ______ nucleus, surrounded by a membrane called a _________.

A

Branching

Central

Sarcolemma

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8
Q

Special contact points where myocardial cells connect

A

Intercalated disks

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9
Q

_________ in the intercalated disks permit rapid conduction of electrical impulses from one cell to the next

A

Gap junctions

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10
Q

Myocytes all contract together as a single unit with stimulated, thanks to _______ which hold the cells together during contraction

A

Desmosomes

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11
Q

The right and left atria are separated by…

A

The interatrial septum

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12
Q

The right and left ventricles are separated by …

A

The interventricular septum

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13
Q

What are the four valves of the heart?

A

Mitral
Tricuspid
Pulmonary
Aortic

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14
Q

What controls the mitral and tricuspid valves?

A

Papillary muscles and chordae tendineae

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15
Q

What does the plate of fibrous connective tissue between the atria and ventricles do?

A

Provides a support structure for the AV and semilunar valves

Separates the upper pumping chambers from the lower chambers

Electrically insulates the atria from the ventricles - electrical impulses in the atria must travel through specific conduction pathways to get to the ventricles

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16
Q

Systole is the _______ phase and diastole is the _______ phase

A

Contraction

Relaxation

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17
Q

The amount of blood ejected from the ventricles during systole

A

Stroke volume

Usually 60-100cc of blood during each systole

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18
Q

What is the formula for cardiac output?

A

Heart Rate x Stroke Volume

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19
Q

Stretching force on the ventricular muscle at end diastole

A

Preload

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20
Q

The pressure against which the heart must pump (ie blood pressure in the aorta)

A

Afterload

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21
Q

Formula for blood pressure

A

Cardiac Output x Peripheral Vascular Resistance

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22
Q

How is the heart regulated?

A

By the brain, via the autonomic nervous system

Hormones of the endocrine system

Heart tissue itself

Receptors monitor adequacy of cardiac output (located in blood vessels, kidneys, brain, heart)

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23
Q

______ detect changes in pressure in the heart and main arteries (aorta and carotid)

A

Baroreceptors

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24
Q

______ detect changes in the chemical composition of the blood

A

Chemoreceptors

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25
Q

Info from baro- and chemoreceptors is transmitted to the ________ in the ________.

A

Cardioregulatory center

Medulla oblongata

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26
Q

Sympathetic Nervous System causes release of _____ and _____ from ________

A

NE and Epi

Adrenal gland

(Why it’s also called the “adrenergic system”)

27
Q

Effects of the Sympathetic NS on the heart

A

Fight or flight response

Speeds heart, increases myocardial excitability

Acts as “cardioaccelerator” - increased pacemaker firing, increased impulse conduction through heart, increased force of contraction, coronary vasodilation

28
Q

In the parasympathetic nervous system, the ________ stimulates the release of ________.

A

Vagus nerve

Acetylcholine

The “cholinergic system”

29
Q

Effects of the parasympathetic NS on the heart

A

Slows heart and slows electrical conduction

“Cardioinhibitor” - decreased rate of SA node pacemaker, decreased rate of conduction through AV node

30
Q

What happens when BP is too low?

A

The cardioregulatory center activates the SYMPATHETIC NS —> NE/Epi release —> Inc HR/contractility, vasoconstriction —> Inc CO and BP

31
Q

What happens when BP is too high?

A

The cardioregulatory center activates the PARASYMPATHETIC NS —> release of ACh —> Dec HR and lower BP

32
Q

What are the key properties of myocardial cells?

A

Automaticity
Excitability
Conductivity
Contractility

33
Q

The ability of certain cells to produce an electrical impulse without outside nerve stimulation

A

Automaticity

A key property of myocardial cells

34
Q

The ability to respond to an electrical stimulus

A

Excitability

A key property of myocardial cells

35
Q

Ability to transmit an electrical stimulus from cell to cell

A

Conductivity

A key property of myocardial cells

36
Q

Ability to contract when electrically stimulated

A

Contractility

A key property of myocardial cells

37
Q

Specialized cardiac cells that generate and transmit electrical impulses throughout the myocardium

A

The conductive pathway

38
Q

What are the 2 types of cells in the conductive pathway?

A

Pacemaker cells - have the ability to spontaneously generate an impulse at a certain rate

Electrical conducting cells - carry the electrical impulses to the appropriate regions of the heart

39
Q

What are the different pacemaker cells?

A

Sinoatrial (SA) node

Atrioventricular (AV) node

Bundle of His

Right and Left Bundle Branches

Purkinje fibers

40
Q

What is the heart’s primary pacemaker?

A

Sinoatrial (SA) node

Located high in the posterior right atrium

41
Q

What is the intrinsic rate of the SA node?

A

60-100 bpm

42
Q

Pacemaker cells located in the low right atrium

A

AV node - pathway for impulses to reach the ventricles

43
Q

The AV node acts as a _______

A

Gatekeeper for impulses reaching the ventricles by conducting impulses more slowly

44
Q

Intrinsic rate of the AV node

A

40-60 bpm

45
Q

Terminal branches of the right and left bundle branches that spread throughout the myocardium

A

Purkinje fibers

46
Q

Intrinsic rate of the purkinje fibers

A

20-40 bpm

Will take over as pacemaker if the SA and AV nodes fail

47
Q

The polarized state (or resting state) of myocardial cells consists of ______ ions inside the cell and _______ ions outside the cell

A

Negatively charged inside

Positively charged outside

48
Q

The ________ is the difference in the electrical charge between inside and outside the cell

A

Resting membrane potential

49
Q

What is depolarization?

A

When positive ions (Na+) enter the cell, the interior becomes positively charged or “depolarized”

Ca2+ ions also enter, but more slowly

THe change in electrical charge over time is called the action potential of the cell

50
Q

What is repolarization?

A

After the cell is depolarized, the positive ions (Na+, Ca2+, K+) leave the cell and the interior of the cell returns to its negatively charged resting state

51
Q

What it’s he absolute refractory period?

A

Following depolarization, the cell becomes temporarily resistant to further depolarization

This keeps the wave of depolarization moving forward but also prevents spasms of continued contraction in one area

52
Q

What is the relative refractory period?

A

In the late phase of repolarization, a very strong electrical stimulus will cause depolarization

53
Q

Who invented the EKG?

A

Willem Einthoven, a Dutch physician and physiologist in 1903 (won Nobel in 1924)

54
Q

_______ leads have electrodes of opposite polarity (positive and negative)

A

Bipolar

Limb leads - Leads I, II, III

55
Q

______ leads have only a positive electrode and a reference point determined by the ECG machine

A

Unipolar leads

Chest/precordial leads (V1-V6)
Augmented limb leads

56
Q

Movement toward a positive electrode appears ______ the baseline on the ECG tracing

A

Above

57
Q

Movement away from a positive (or towards a negative) electrode appears ______ the baseline

A

Below

58
Q

The ECG records the sum of all…

A

The small directional electrical currents

These are called vectors and their sum is the electrical axis

59
Q

______ = many small electrical currents in various directions

______ = overall direction of the same of the vectors

A

Vectors

Axis

60
Q

The _______ represents atrial depolarization

A

P wave

61
Q

The ______ represents ventricular depolarization

A

QRS wave

62
Q

The _______ represents ventricular repolarization

A

T wave

63
Q

Why is atrial repolarization not represented on the ECG?

A

B/c it’s hidden in the QRS wave