1 Intro and Electrophysiology Flashcards
What is the pericardial sac?
The tough fibrous sac that encloses the heart
What are the layers of the pericardial sac?
Parietal pericardium (outer)
Visceral pericardium (inner)
Pericardial fluid in between, lubricating the two layers
What are the three layers of the heart wall?
Epicardium - thin serous membrane on outer aspect of the heart
Myocardium - the muscular middle layer
Endocardium - thin serous membrane lining the inner chambers and valves
What are the two basic cell types in the heart?
Myocardial cells - have contractile ability
Conducting cells - pacemaker cells and electrical conducting cells
Describe the myocardial cells
“Working cells” of the heart
Consist of latticework of protein filaments (myosin and actin)
The branching network of myocardial cells in the heart is called…
A syncytium
Cardiomyocytes are ________ cells with a ______ nucleus, surrounded by a membrane called a _________.
Branching
Central
Sarcolemma
Special contact points where myocardial cells connect
Intercalated disks
_________ in the intercalated disks permit rapid conduction of electrical impulses from one cell to the next
Gap junctions
Myocytes all contract together as a single unit with stimulated, thanks to _______ which hold the cells together during contraction
Desmosomes
The right and left atria are separated by…
The interatrial septum
The right and left ventricles are separated by …
The interventricular septum
What are the four valves of the heart?
Mitral
Tricuspid
Pulmonary
Aortic
What controls the mitral and tricuspid valves?
Papillary muscles and chordae tendineae
What does the plate of fibrous connective tissue between the atria and ventricles do?
Provides a support structure for the AV and semilunar valves
Separates the upper pumping chambers from the lower chambers
Electrically insulates the atria from the ventricles - electrical impulses in the atria must travel through specific conduction pathways to get to the ventricles
Systole is the _______ phase and diastole is the _______ phase
Contraction
Relaxation
The amount of blood ejected from the ventricles during systole
Stroke volume
Usually 60-100cc of blood during each systole
What is the formula for cardiac output?
Heart Rate x Stroke Volume
Stretching force on the ventricular muscle at end diastole
Preload
The pressure against which the heart must pump (ie blood pressure in the aorta)
Afterload
Formula for blood pressure
Cardiac Output x Peripheral Vascular Resistance
How is the heart regulated?
By the brain, via the autonomic nervous system
Hormones of the endocrine system
Heart tissue itself
Receptors monitor adequacy of cardiac output (located in blood vessels, kidneys, brain, heart)
______ detect changes in pressure in the heart and main arteries (aorta and carotid)
Baroreceptors
______ detect changes in the chemical composition of the blood
Chemoreceptors
Info from baro- and chemoreceptors is transmitted to the ________ in the ________.
Cardioregulatory center
Medulla oblongata