1.) Degenerative Arthritis Flashcards
What is the aka of Degenerative Joint Disease (DJD)?
Osteoarthritis
What type of arthritis is degenerative joint disease?
Wear and tear
What are 3 examples from the notes of confusing terminology in the spine?
1.) Intervertebral osteochondrosis 2.) Spondylosis deformans 3.) Discogenic spondylosis
Does degenerative joint disease create spurs?
No
What are the 2 type of nodal osteoarthritis in the hands?
1.) Heberden’s Nodes 2.) Bouchard’s Nodes
What are the 3 most common locations of localized idiopathic osteoarthritis in the hands?
1.) Nodes 2.) Erosive interphalangeal joints 3.) Carpal - 1st metacarpal joint
What are the 2 types of contracted toe positions caused by localized idiopathic osteoarthritis?
1.) Hammer toes 2.) Cock-up toes
What are the 3 most common locations of localized idiopathic osteoarthritis in the feet?
1.) Hallux valgus or rigidus 2.) Contracted toes 3.) Talonavicular joint
What are the 3 most common locations of localized idiopathic osteoarthritis in the knees?
1.) Medial compartment 2.) Lateral compartment 3.) Patellofemoral compartment
What is an aka for superior migration in the hip caused by localized idiopathic osteoarthritis?
Eccentric
What is an aka for axial or medial migration in the hip caused by localized idiopathic osteoarthritis?
Concentric
What is an aka for diffuse migration in the hip caused by localized idiopathic osteoarthritis?
Coxae senilis
What are the 3 most common locations of localized idiopathic osteoarthritis in the hip?
1.) Eccentric (superior) 2.) Concentric (axial, medial) 3.) Diffuse (coxae senilis)
What are the 4 most common locations of localized idiopathic osteoarthritis in the spine?
1.) Apophyseal joints 2.) Intervertebral discs 3.) Spondylosis (osteophytes) 4.) Ligamentous (DISH)
What are 4 other isolated joints from the notes that are common locations of localized idiopathic osteoarthritis?
1.) Sacroiliac (SI) joint 2.) Temporomandibular Joint (TMJ) 3.) Glenohumeral joint 4.) Tibiotalar joint
What are the 6 causes from the notes of secondary osteoarthritis?
1.) Trauma 2.) Congenital or developmental disorders 3.) Metabolic disorders 4.) Endocrine disorders 5.) Calcium deposition diseases 6.) Neuropathic disorders
What are the 5 examples from the notes of trauma that can result in secondary osteoarthritis?
1.) Acute trauma 2.) Chronic trauma (occupation, sports) 3.) Frostbite 4.) Caisson disease 5.) Hemoglobinopathies
What are 3 examples from the notes of localized congenital or developmental disorders that can result in secondary osteoarthritis?
1.) Legg-Calve-Perthes disease 2.) Developmental dysplasia of the Hip 3.) Slipped Femoral Capital Epiphysis (SFCE)
What are 3 examples from the notes of congenital or developmental mechanical factors that can result in secondary osteoarthritis?
1.) Varus/valgus 2.) Unequal leg length 3.) Hypermobility syndromes 4.) Bone dysplasias
What are 4 examples from the notes of metabolic disorders that can result in secondary osteoarthritis?
1.) Ochronosis 2.) Hemachromatosis 3.) Wilson’s disease 4.) Gaucher’s disease
What are 5 examples from the notes of endocrine disorders that can result in secondary osteoarthritis?
1.) Acromegaly 2.) Hyperparathyroidism 3.) Diabetes 4.) Obesity 5.) Hypothyroidism
What are 2 examples from the notes of calcium deposition diseases that can result in secondary osteoarthritis?
1.) Calcium Pyrophosphate Deposition Disease (CPPD) 2.) Apatite arthropathy
What are 4 risk factors of occupational trauma that are associated with increased incidences of osteoarthritis in the knee?
1.) Kneeling 2.) Squatting 3.) Bending 4.) Heavy lifting
Professional level athletes have an _____ incidence of osteoarthritis?
Increased
Former long distance runners and tennis players have a _____x increased risk of osteoarthritis in the knees and hips.
2-3x
Soccer athletes with an ACL tear have a _____x increased risk of osteoarthritis in the knee compared to athletes with an intact ACL.
3x
According to the Framingham study what is a strong predictor of later osteoarthritis?
Obesity as a young adult
It is estimated that elimination of obesity would reduce knee osteoarthritis by how much?
25-50%
It is estimated that elimination of obesity would reduce hip osteoarthritis by how much?
25% or more
What are the genetic risk factors of osteoarthritis?
Heberden’s nodes
What are Heberden’s nodes?
Nodal osteoarthritis in the distal interphalangeal joints
What are 6 risk factors for the progression (not onset) or osteoarthritis in the knee?
1.) Female 2.) Increased age 3.) Overweight 4.) Heberden’s nodes 5.) Low dietary vitamin C 6.) Low dietary vitamin D
Do most individuals with x-ray demonstrable osteoarthritis have joint symptoms?
No
Who has an increased risk factor of osteoarthritis: men or women?
Women
Who has an increased risk factor of osteoarthritis: People in welfare or working people?
People on welfare
Who has in increased risk factor of osteoarthritis: Married people or divorced people?
Divorced people
What are 8 characteristics from the notes of the gross pathology of osteoarthritis?
1.) Softening, fibrillation and loss of articular cartilage 2.) Eburnation of exposed bone/bone remodeling 3.) Osteophytes 4.) Subchondral cysts 5.) Synovitis 6.) Thickening of joint capsule 7.) Meniscus degeneration 8.) Periarticular muscle atrophy
Early osteoarthritis is characterized by a healing response with what 3 components?
1.) Thickening of the articular cartilage 2.) Increased water content 3.) Increased rate of proteoglycan synthesis
What are the 4 component in the progression of cartilage changes in osteoarthritis?
1.) Decreased proteoglycan concentration 2.) Cartilage thinning 3.) Vertical clefts (fibrillation) in cartilage 4.) Irregular fibrillated cartilage is worn away
Normal articular cartilage is avascular and separated from underlying bone by what?
A layer of calcified cartilage (tidemark)
When fibrocytes migrate into fissures in cartilage what do they produce?
Fibrocartilage
Which is more durable: Fibrocartilage or hyaline cartilage?
Hyaline cartilage
What are 4 bone changes from the notes in osteoarthritis?
1.) Remodeling and hypertrophy of subchondral bone occurs 2.) Eburnation of bone 3.) Subchondral cyst formation 4.) Osteophytes
How does remodeling and hypertrophy of subchondral bone present on radiographs?
Sclerosis
What is eburnation?
Smooth, polished appearance of exposed subchondral bone after articular cartilage has worn away
What is subchondral cyst formation?
Microfractures of the bone allows synovial fluid to penetrate subchondral bone
What bone changes that occur with osteoarthritis result in osteophytes?
Combined growth of cartilage and bone at joint margins
What are 3 synovial changes from the notes that result from osteoarthritis?
- ) Chronic, patchy synovitis changes
- ) Villous formation may occur
- ) Fragments of artiular cartilage and bone may become embedded in synovial membrane
Chronic, patchy synovitis that occurs with osteoarthritis usually occurs with what 3 things?
- ) Lining cell hyperplasia
- ) Lymphocytic infiltration
- ) Perivascular lymphoid aggregates
Villous formation which may occur with osteoarthritis is reminescent of rheumatoid arthritis, how does it differ?
- ) No pannus formation
- ) No erosion of cartilage
What surrounds the fragments of articular cartilage and bone when they become embedded in the synovial membrane?
- ) Macrophages
- ) Local inflammatory cells
Intervetebral osteochondrosis primarily affect what target tissue?
The nucleus pulposis
In intervetebral osteochondrosis dessication of the nucleus leads to what 2 things?
- ) Vacuum phenomenon in IVD space
- ) Decreased IVD height
What disorder is pictured?
Intervertebral osteochondrosis
What condition is pictured?
Intervertebral osteochondrosis
What condition is pictured?
Intervertebral osteochondrosis
What condition is pictured?
Intervertebral osteochondrosis
Spondylosis deformans primarily affects what target tissue?
Annular fibers of the disc
What are the key findings of spondylosis deformans?
Osteophytes on the vertebral endplates
What type of arthritis does a syndesmophyte typically imply?
Inflammatory arthritis
What is the typical location of spondylosis deformans?
Marginal location
What condition is pictured?
Spondylosis deformans
What condition is pictured?
Spondylosis deformans
What type of appearance is pictured in this cervical spine?
Pseudo-fracture appearance
What type of appearance is pictured in this cervical spine?
Pseudo-fracture appearance