1 Flashcards
Supranuclear Palsy symptoms
Dysarthria, dysphagia, and symmetric axial rigidity (stiff unstable posture), toppling gait
Initially presents with executive function and personality changes
Second Impact Syndrome
Brain swelling that occurs after even minor brain injuries following an initial concussion
Coup and Contrecoup injuries
intraparenchymal hemorrhage of thefrontal lobes, anterior temporal
subarachnoid hemorrhages can also occur
Aβ protein
Abnormal protein in Alzheimer’s disease derived from APP after cleavage by β and γ secretases.
Cleavage of β secretase product by γ secretase results in toxic Aβ42 or the nontoxic Aβ40 peptide;
Cleavage of the α secretase product by γ secretase produces the nontoxic P3 peptide.
Amyloid plaques
found in Alzheimer’s disease, made up of Aβ protein
Anton’s Syndrome
Cortical blindness + other cortical lesions
Patients deny their blindness despite objective evidence of visual loss, and moreover confabulate to support their stance.
Fregoli Delusion
Delusion that different people the person meets are all actually 1 person in different disguises
Can be caused by injury to R Frontal + L Temporoparietal areas
One of the delusional misidentification syndromes
Capgras Delusion
Delusion that a someone close to the person has been replaced by an impostor
One of the delusional misidentification syndromes
Cotard Delusion
Delusional belief that the person is dead, is decomposing, or missing their internal organs, or does not exist
Possibly related to dysfunction of fusiform gyrus (fusiform face area)
Todd’s Syndrome/Alice in Wonderland Syndrome
Distortions in size and depth perception
Raccoon Sign
Periorbital ecchymosis due to basilar skull fracture
Battle’s Sign
Postauricular ecchymosis (over the mastoid process) due to middle fossa fracture/temporal bone fracture
Mild Cognitive Impairment to Dementia
50% of people with MCI develop dementia in 3 years
Anosmia + Lack of taste
Occipital head injuries = leads to shearing of olfactory nerves through cribriform plate
Brain atrophy in Alzheimer’s
More focused on posterior cortex and medial temporal lobes.
Earliest and most severe degeneration is usually found in the medial temporal lobe (entorhinal/perirhinal cortex and hippocampus), lateral temporal cortex, and nucleus basalis of Meynert.
Median nerve injury
Carpal Tunnel Syndrome
hand of benediction (looks like ulnar claw but occurs when trying to make a fist)
Ulnar Nerve Entrapment
4th and pinkie finger (ulnar claw)
Weakened intrinsic muscles
Biceps Reflex
C5-C6 (Biceps/Brachioradialis)
Triceps Reflex
C7-C8 (Triceps)
Patellar Reflex
L3-L4 (Quads)
Cremasteric Reflex
L1-L2 (Cremasteric muscle)
Ankle Reflex
S1-S2 (Gastrocnemius)
Anal Wink Reflex
S3-S4 (Anal sphincter)
Deep brain hemorrhages (basal ganglia and other regions)
Shearing forces
Percentage of delirium cases with pre-existing history of dementia
2/3 (67%)