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Question 1

Painless bleeding after intercourse in a pregnant woman is what?

Answer 1

Placenta praevia

Question 2

What are the clinical features found in antepartum haemorrhage?

Answer 2

Abdo pain
Bleeding from vag
Irritable uterus

Question 3

When does primary post partum haemorrhage occur?

Answer 3

First 24hrs of delivery

Question 4

When does secondary post partum haemorrhage occur?

Answer 4

24hrs to 6 weeks after delivery

Question 5

What drug can be given to a patient who as tried the conservative approach to improving their stress incontinence/

Answer 5

Duloxetine

SNRI

Question 6

What is a dominant negative mutation?

Answer 6

Mutated gene produces a mutated protein that does not function + binds to and inhibits the function of non-mutated proteins

Question 7

What is a nonsense mutation?

Answer 7

Change in nucleotide sequence that creates a stop codon

Question 8

What is a missense mutation?

Answer 8

A change in nucleotide code which results in one amino acid being substituted for another

Question 9

What does rituximab kill?

Answer 9

B cells (can’t make antibodies but also can’t make autoantibodies)

Question 10

What score is used for predicting a short-term risk for stroke after a TIA?

Answer 10

ABCD2

Question 11

What is Wells score used to assess?

Answer 11

DVT risk

Question 12

How does a 22q11 deletion present (diGeorge syndrome)?

Answer 12

Cardiac - ouflow lesions, VSD
Thymic aplasia
Nasal regurgitation
Cleft apalate
Deafness
Hypocalcaemia
Facial dysmorphism

Question 13

How does De Lange syndrome present?

Answer 13

Absent hands/forearms

Question 14

What is the pathology of Patau syndrome?

Answer 14

Trisomy 13

Question 15

What are the clinical features of Patau syndrome?

Answer 15

Midline cleft lip palate
Omphalocele
Cardiac defects
Holoprosencephaly
Hypotelorism

Question 16

Describe how Huntigton’s is inherited?

Answer 16

Autosomal dominant triplet repeat (CAG)disease affecting chromosome 4