1

Question 1

absorption

Answer 1

the process of a substance entering the systemic circulation

Question 2

distribution

Answer 2

the dispersion of a substance throughout fluids and tissues of the body

Question 3

metabolism (liver)

Answer 3

the transformation of parent compounds into daughter compounds–>biotransformation–> more polar –> to activate them

Question 4

excretion (renal)

Answer 4

the removal of the substance from the body

Question 5

excretion sites

Answer 5

renal/kidney

Question 6

metabolism sites

Answer 6

the liver

Question 7

distribution sites

Answer 7

vascular space (blood/plasma) to extravascular space (fat, muscles, interstitial space)

Question 8

absorption site

Answer 8

depends on the mother fucking route of administration

Question 9

a loading dose

Answer 9

a higher dose than required to compensation for the slow rater of absorption, low plasma concentration

Question 10

[concentration]

Answer 10

mass/volume

Question 11

mass

Answer 11

amount of drug, mg

Question 12

blood volume

Answer 12

5L

Question 13

plasma volume

Answer 13

blood volume-cell=2.5L

Question 14

1cc (cubic centimeters)

Answer 14

1cc=1ml

Question 15

a 10mg of drug X is 100% absorbed, what is the plasma drug concentration

Answer 15

10mg/2.5L

Question 16

bolus

Answer 16

given all at once

Question 17

serum

Answer 17

plasma -clotting factors

Question 18

bioavailability

Answer 18

the fraction of the administsered dose that reaches the systemic circulation

AUC route/AUC iv

Question 19

area under the curve

Answer 19

proportional to the amount of drug absorbed

Question 20

if the oral bioavailability of a drug id 50%. if theIV dose is 50 mg what should the oral does be?

Answer 20

100mg

50ml/2.5L=0.5*(X/2.5L)

or

Mass (plasma mass)= Mass (adminstered) * bioavailability

Question 21

volume of distribution, Vd

Answer 21

total mass absorbed (mass adminstered* bioabailability)/plasma concentration

Question 22

what affects volume of distribution

Answer 22

high molecular weight, stay in plasma

binding to plasma protein decreases Vd

hydrophilic, low Vd 9staysin the plasma)

lipophillic. high Vd

Question 23

where does metabolism occur?

Answer 23

in dat liver, smooth endoplasmic reticulium (the rough is used in protein synthesis)

Question 24

first pass metabolism

Answer 24

goes through the portal vein, metabolised before it reaches the systemic circulation. Oral and rectal

Question 25

phase 1 metabolism uses what

Answer 25

CYP450, alcohol dehydrogenase

Question 26

Phase 2 metabolism uses what

Answer 26

conjugation reactions

glucuronidation

sulfation

acetylation