1 Flashcards

1
Q
Which of the following conditions would cause a positive Kussmaul's sign on physical
examination?
Answers
A. Left ventricular failure
B. Pulmonary edema
C. Coarctation of the aorta
D. Constrictive pericarditis
A

(u) A. Left ventricular failure results in the back-up of blood into the left atrium and then the
pulmonary system so it would not be associated with Kussmaul’s sign.
(u) B. Pulmonary edema primarily results in increased pulmonary pressures rather than having
effects on the venous inflow into the heart.
(u) C. Coarctation of the aorta primarily affects outflow from the heart due to the stenosis resulting
in delayed and decreased femoral pulses; it has no effect on causing Kussmaul’s sign.
(c) D. Kussmaul’s sign is an increase rather than the normal decrease in the CVP during
inspiration. It is most often caused by severe right-sided heart failure; it is a frequent finding in
patients with constrictive pericarditis or right ventricular infarction.

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2
Q

Anginal chest pain is most commonly described as which of the following?
Answers
A. Pain changing with position or respiration
B. A sensation of discomfort
C. Tearing pain radiating to the back
D. Pain lasting for several hours

A

(u) A. Pain changing with position or respiration is suggestive of pericarditis.
(c) B. Myocardial ischemia is often experienced as a sensation of discomfort lasting 5-15 minutes,
described as dull, aching or pressure.
(u) C. Tearing pain with radiation to the back represents aortic dissection.
(u) D. Chest pain lasting for several hours is more suggestive for myocardial infarction.

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3
Q

Eliciting a history from a patient presenting with dyspnea due to early heart failure, the
severity of the dyspnea should be quantified by
Answers
A. amount of activity that precipitates it.
B. how many pillows they sleep on at night.
C. how long it takes the dyspnea to resolve.
D. any associated comorbidities.

A

(c) A. The amount of activity that precipitates dyspnea should be quantified in the history.
(u) B. Orthopnea or paroxysmal nocturnal dyspnea can be quantified by how many pillows a
patient needs to sleep on to be comfortable.
(u) C. How long dyspnea takes to resolve or associated comorbidities has no bearing on
quantifying the severity of dyspnea.
(u) D. See answer C above.

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4
Q

A 25 year-old female presents with a three-day history of chest pain aggravated by
coughing and relieved by sitting. She is febrile and a CBC with differential reveals
leukocytosis. Which of the following physical exam signs is characteristic of her problem?
Answers
A. Pulsus paradoxus
B. Localized crackles
C. Pericardial friction rub
D. Wheezing

A

(u) A. Pulsus paradoxus is a classic finding for cardiac tamponade.
(u) B. Localized crackles are associated with pneumonia and consolidation, not pericarditis.
(c) C. Pericardial friction rub is characteristic of an inflammatory pericarditis.
(u) D. Wheezing is characteristic for pulmonary disorders, such as asthma.

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5
Q

A 65 year-old white female presents with dilated, tortuous veins on the medial aspect of
her lower extremities. Which of the following would be the most common initial
complaint?
Answers
A. Pain in the calf with ambulation
B. Dull, aching heaviness brought on by periods of standing
C. Brownish pigmentation above the ankle
D. Edema in the lower extremities

A

(u) A. Patients with deep venous thrombosis (DVT) may present with complaints of pain in the
calf with ambulation. Secondary varicosities may result from DVT’s.
(c) B. Dull, aching heaviness or a feeling of fatigue brought on by periods of standing is the most
common complaint of patients presenting initially with varicosities.
(u) C. Stasis Dermatitis and edema are most suggestive of chronic venous insufficiency.
(u) D. See C for explanation.

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6
Q

A 22 year-old male received a stab wound in the chest an hour ago. The diagnosis of
pericardial tamponade is strongly supported by the presence of
Answers
A. pulmonary edema.
B. wide pulse pressure.
C. distended neck veins.
D. an early diastolic murmur.

A

(u) A. Pulmonary edema may result with low output states as seen with myocardial contusions,
but it is not strongly suggestive of tamponade.
(u) B. Wide pulse pressure is seen in conditions of high stroke volume such as aortic insufficiency
or hyperthyroidism. Narrow pulse pressure is seen with cardiac tamponade.
(c) C. Cardiac compression will manifest with distended neck veins and cold clammy skin.
(u) D. The onset of diastolic murmur is suggestive of valvular disease, not tamponade.

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7
Q

A patient presents with a rash, characterized by red macules and edematous papules with
a clearing center. This best describes which of the following?
Answers
A. erythema marginatum
B. erythema multiforme
C. varicella
D. impetigo

A

(u) A. Erythema marginatum is associated with rheumatic fever and is characterized by macular
to maculopapular lesions. A clearing center is not found in the rash.
(c) B. Target lesions, also termed iris lesions, are characteristic of erythema multiforme. The rash
may be recurrent but typically resolves over 3-6 weeks.
(u) C. The rash of varicella typically has maculopapules, vesicles, and scabs in various stages of
development. A clearing center is not found in the rash.
(u) D. The lesions of impetigo are pustules that form a honey-colored crust after rupturing.

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8
Q
In a patient suspected of having seborrheic dermatitis, the most common site of
involvement would be the
Answers
A. upper extremities.
B. thighs.
C. scalp.
D. feet.
A

(u) A. See C for explanation.
(u) B. See C for explanation.
(c) C. The most common site of involvement of seborrheic dermatitis is the scalp. Other common
sites include the eyebrows, eyelids, nasolabial fold, and ears.
(u) D. See C for explanation.

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9
Q

A 26-year-old obese female complains of a 3-4 month history of discrete erythematous
plaques on the pretibial areas of her legs. The lesions have increased in size, become
darker, and are painful. She is concerned because the centers of the lesions have become
ulcerated. This patient should be screened for which of the following?
Answers
A. Hypothyroidism
B. Diabetes mellitus
C. Melanoma
D. Scleroderma

A

(u) A. In hypothyroidism the skin of the pretibial area may thicken leading to edema. This is a
diffuse finding, involving the face and eyelids, without discrete lesions.
(c) B. The description of the skin lesions is characteristic of necrobiosis lipoidica diabeticorum,
one of the dermatologic manifestations of diabetes mellitus.
(u) C. The lesions of melanoma are typically not painful and do not ulcerate.
(u) D. Scleroderma is marked by thickening of the skin, with swelling of the fingers and hands.
The swelling may involve the forearms and face; the lower extremities are relatively spared.

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10
Q

A 40 year-old male presents to your clinic complaining of nontender, yellow patches on
both eyelids. He states his brother and uncle have similar growths. He denies any visual
changes or other complaints. Your primary suspicion is
Answers
A. gout.
B. lipoma.
C. hyperlipidemia.
D. seborrheic dermatitis.

A

(u) A. Tophaceous gout may appear as yellow skin lesions but they usually occur around the
joints and helix of the ear.
(u) B. Lipomas tend to be flesh-colored and are not usually bilateral.
(c) C. Xanthelasmas, along with xanthomas, are common findings in familial
hypercholesterolemia.
(u) D. Eyelids are a common location for seborrheic dermatitis but the lesions are not yellow in
color

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11
Q

A 4 year-old child presents with a rapid onset of high fever and extremely sore throat.
Which of the following findings are suggestive of the diagnosis of epiglottitis?
Answers
A. Croupy cough and drooling
B. Thick gray, adherent exudate
C. Beefy red uvula, palatal petechiae, white exudate
D. Inflammation and medial protrusion of one tonsil

A

(c) A. A croupy cough with drooling in a patient who appears very ill is consistent with epiglottitis.
Examining the throat is contraindicated, unless the airway can be maintained.
(u) B. Thick gray adherent exudate is suggestive of diphtheria.
(u) C. Beefy red uvula, palatal petechiae, and white exudate are findings suggestive of
streptococcal pharyngitis.
(u) D. Inflammation with medial protrusion of the tonsil is suggestive of a peritonsillar abscess.

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12
Q

Which of the following are normal findings in a Weber test?
Answers
A. The tympanic membrane is movable with pneumatic otoscopy.
B. The tympanic membrane is pearly gray with a sharp cone of light with apex at the umbo.
C. Sound is heard equally in both ears when a vibrating tuning fork is placed on the mid forehead.
D. Air conduction is greater than bone conduction when a vibrating tuning fork is moved from the
mastoid bone to close to the ear canal.

A

(u) A. A movable tympanic membrane indicates there is no effusion, and is not the Weber test.
(u) B. The tympanic membrane is evaluated by direct observation with an otoscope, and is not
the Weber test.
(c) C. A normal Weber test means there is no lateralization of sound perception when a vibrating
tuning fork is placed on the mid forehead.
(u) D. A normal Rinne test means that tuning fork vibration is heard longer through the air than
the bone.

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13
Q
Which of the following is diagnosed by use of the cover/uncover test?
Answers
A. Adie’s pupil
B. Strabismus
C. Glaucoma
D. Myopia
A

(u) A. Adie’s pupil is a sluggish pupil reaction to light and accommodation, evaluated by papillary
reaction to light.
(c) B. The cover/uncover test is used to diagnose strabismus.
(u) C. Tonometry is used to measure intraocular pressure to evaluate for glaucoma.
(u) D. Myopia is evaluated by using a Snellen chart.

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14
Q

A patient is known to have end stage liver disease due to cirrhosis. Which of the following
physical examination findings would commonly be seen in this patient?
Answers
A. Testicular hypertrophy
B. Muscular pseudohypertrophy
C. Gynecomastia
D. Hepatomegaly

A

(u) A. Testicular atrophy, wasting of the muscles of the lower extremity, spider angiomas, caput
medusa and gynecomastia are physical examination findings associated with end stage liver
disease associated due to cirrhosis.
(u) B. Muscular pseudohypertrophy is seen in muscular dystrophy.
(c) C. See A for explanation.
(u) D. Patients with end stage liver failure who have cirrhosis have a small shrunken liver from the
ongoing cellular destruction and fibrosis.

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15
Q
Which of the following is the most consistent physical examination finding in a patient
with duodenal ulcer?
Answers
A. Flank tenderness
B. Right upper quadrant tenderness
C. Epigastric tenderness
D. Rebound tenderness
A

(u) A. Flank tenderness is caused by urologic disorders such as pyelonephritis and renal lithiasis.
(u) B. Right upper quadrant tenderness on palpation is a typical feature for cholecystitis.
(c) C. Epigastric tenderness is a key feature of duodenal ulcer.
(u) D. Rebound tenderness is a feature of peritonitis from rupture of a hollow viscus and is not
seen with just the presence of duodenal ulcer.

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16
Q
The initial sign or symptom of iron poisoning in a 3 year-old child is usually
Answers
A. vomiting and bloody diarrhea.
B. convulsions and tetany.
C. somnolence and coma.
D. ataxia and colicky abdominal pain.
A

(c) A. Iron causes localized necrosis and hemorrhage at the point of contact in the GI system
resulting in abdominal pain, vomiting, bloody diarrhea, and hematemesis.
(u) B. Convulsions and tetany are symptoms of hypocalcemia.
(u) C. Somnolence and coma are not initial findings in iron ingestion.
(u) D. Ataxia and colicky abdominal pain are consistent with lead poisoning.

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17
Q

A classic skin finding seen in patients with inflammatory bowel disease would be
Answers
A. erythematous plaques on the extremities.
B. poorly healing, indolent ulcers on the lower extremities.
C. pretibial myxedema.
D. purple striae.

A

(u) A. Granuloma annulare is seen with diabetes mellitus. It consists of erythematous plaques on
the extremities or trunk.
(c) B. Pyoderma gangrenosum is classically seen with inflammatory bowel disease and is rarely
seen in the absence of inflammatory bowel disease.
(u) C. Pretibial myxedema is the skin manifestation of hyperthyroidism.
(u) D. The dermatologic manifestations of Cushing’s disease are purple striae and a
supraclavicular fat pad.

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18
Q
A 55-year-old non-smoking male presents with a hemoglobin of 18.5 g/dl and a hematocrit
of 56%. Which of the following physical examination findings is the most likely to be
noted with this patient?
Answers
A. Splenomegaly
B. Cheilosis
C. Purpura
D. Decreased vibratory sense
A

(c) A. Patients with polycythemia vera present with elevated hemoglobin and hematocrit. On
physical examination plethora, engorged retinal veins, and splenomegaly are common.
(u) B. Cheilosis is noted in iron deficiency anemia.
(u) C. Purpura is typically noted in bleeding disorders.
(u) D. Decreased vibratory sense is noted in vitamin B12 deficiency.

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19
Q

A 73 year-old male presents to the clinic with his wife. His wife has noticed that he has
developed a resting tremor in his right hand and a shuffling gait over the last year. What
finding on physical examination would support your suspected diagnosis?
Answers
A. Chorea
B. Dystonia
C. Masked facies
D. Hyperreflexia

A

(u) A. See C for explanation.
(u) B. See C for explanation.
(c) C. The patient symptoms are consistent with Parkinsonism. Physical exam findings include
masked facies, micrographia, decreased arm swing, and monotonous speech.
(u) D. See C for explanation.

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20
Q
A patient with an upper motor neuron lesion would exhibit which of the following
findings?
Answers
A. Fasciculations
B. Areflexia
C. Muscular atrophy
D. Spasticity
A

(u) A. Fasciculations, areflexia and muscle atrophy are consistent with lower motor neuron
lesions.
(u) B. See A for explanations.
(u) C. See A for explanation.
(c) D. Spasticity is an upper motor neuron lesion finding.

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21
Q

On examination of a pregnant patient the physician assistant notes a bluish or purplish
discoloration of the vagina and cervix. This is called
A. Hegar’s sign.
B. McDonald’s sign.
C. Cullen’s sign
D. Chadwick’s sign

A

(u) A. Hegar’s sign is the softening of the cervix that often occurs with pregnancy.
(u) B. McDonald’s sign is when the uterus becomes flexible at the uterocervical junction at 7-8
weeks.
(u) C. Cullen’s sign is a purplish discoloration periumbilical and noted in pancreatitis.
(c) D. Chadwick’s sign is a bluish or purplish discoloration of the vagina and cervix.

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22
Q

On examination of a pregnant patient the physician assistant notes the fundal height is at
the level of the umbilicus. This corresponds to what gestational age?
Answers
A. 16 weeks
B. 20 weeks
C. 24 weeks
D. 28 weeks

A

(u) A. See B for explanation.
(c) B. At 20-22 weeks the fundal height is typically at the level of the umbilicus.
(u) C. See B for explanation.
(u) D. See B for explanation.

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23
Q
Which of the following is the most common manifestation of polycystic ovarian
syndrome?
Answers
A. Desquamation
B. Hirsutism
C. Galactorrhea
D. Rebound tenderness
A

(u) A. Desquamation is noted in toxic shock syndrome.
(c) B. The patient with polycystic ovarian syndrome typically presents with hirsutism or infertility.
(u) C. Galactorrhea is noted in hyperprolactinemia.
(u) D. Rebound tenderness is noted in conditions causing peritonitis.

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24
Q
Abduction of the shoulder against resistance helps localize pain in which of the following
muscles of the shoulder girdle?
Answers
A. Supraspinatus
B. Infraspinatus
C. Teres minor
D. Subscapularis
A

(c) A. Abduction against resistance tests the supraspinatus.
(u) B. Lateral rotation against resistance tests the infraspinatus and teres minor.
(u) C. See B for explanation.
(u) D. Medial rotation against resistance tests the subscapularis.

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25
Q

A 22 year-old male presents to the ED after sustaining a blow to the knee during football
practice. The knee exam demonstrates significant forward translation of the tibia when
the knee is in 15 degrees of flexion and external rotation at the hip. Which of the following
knee maneuvers does this represent?
Answers
A. Abduction stress test
B. Anterior drawer sign
C. Lachman test
D. McMurray test

A

(u) A. The abduction stress test is performed to evaluate medial collateral ligament tears while
applying valgus stress.
(u) B. The anterior drawer sign is performed to evaluate the anterior cruciate ligament; however
the patient is supine, hips and knees flexed, and feet are flat on the table.
(c) C. The Lachman test is performed to evaluate the anterior cruciate ligament. The knee is
placed in 15 degrees of flexion and external rotation of the hip.
(u) D. The McMurray test is performed to

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26
Q

A 12 year-old female presents for a routine sports physical. The physical exam reveals
asymmetry of the posterior chest wall on forward bending. This is the most striking and
consistent abnormality of which of the following?
Answers
A. Spondylolysis
B. Spondolisthesis
C. Scoliosis
D. Herniated disc

A

(u) A. Spondylolysis presents with limitation of lumbar flexibility and tight hamstring muscles.
(u) B. Spondylolisthesis presents with reduced lumbar lordosis and sacral kyphosis.
(c) C. Asymmetry of the posterior chest wall on forward bending is the most striking and
consistent abnormality in patients with idiopathic scoliosis.
(u) D. Herniated disc presents with lumbar muscle spasm and a positive straight leg test.

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27
Q

Physical exam findings in a 4 year-old child that include blue sclerae and recurrent
fractures indicates which of the following?
Answers
A. Ehlers-Danlos syndrome
B. Marfan syndrome
C. Achondroplasia
D. Osteogenesis imperfecta

A

(u) A. Physical exam findings in Ehlers-Danlos include laxity and hypermobility of joints, mitral
valve prolapse, and associated degenerative arthritis.
(u) B. Children with Marfan syndrome have hypotonia, arachnodactyly, joint laxity and
dislocations.
(u) C. Children with achondroplasia are below normal standards on growth charts. They have
difficulty balancing their large heads when beginning to walk.
(c) D. Mild osteogenesis imperfecta presents with blue sclerae, history of recurrent fractures and
presenile deafness.

28
Q

Which of the following historical factors differentiates post-traumatic stress disorder from
acute stress disorder?
Answers
A. The inability of the person to recall an important aspect of the event.
B. Avoidance of stimuli that invokes recollections of the event.
C. A belief that their future has been foreshortened because of the event.
D. The presence of sleep disorder.

A

(u) A. See C for explanation.
(u) B. See C for explanation.
(c) C. Post-traumatic stress disorder and acute stress disorder have many of the same
characteristics. A sense of a foreshortened future, such as not expecting a normal life span or a
career due to the trauma, distinguishes post-traumatic stress disorder from an acute stress
disorder. The other answers are

29
Q
A patient with obsessive-compulsive disorder would most likely have which of the
following findings?
Answers
A. Raw, red hands
B. Priapism
C. Memory impairment
D. Abdominal pain
A

(c) A. Common manifestations of obsessive-compulsive disorder include phobias of germ and
contaminants, which results in frequent hand washing leading to chafe and reddened hands. The
other answers are inconsistent with obsessive-compulsive disorder.

30
Q

A 45 year-old male presents with sudden onset of pleuritic chest pain, productive cough
and fever for 1 day. He relates having symptoms of a “cold” for the past week that
suddenly became worse yesterday. Which of the following findings will most likely be
seen on physical examination of this patient?
Answers
A. spoken “ee” heard as “ay”
B. hyperresonant percussion note
C. wheezes over the involved area
D. vesicular breath sounds over involved area

A

(c) A. This patient most likely has a bacterial pneumonia with consolidation, which would produce
egophony, where a spoken “ee” is heard as “ay.”
(u) B. Consolidation from bacterial pneumonia causes findings of dullness to percussion, late
inspiratory crackles and bronchial breath sounds over the involved area.
(u) C. See explanation B.
(u) D. See explanation B.

31
Q
Which of the following is a common symptom associated with laryngotracheobronchitis
(viral croup)?
Answers
A. drooling
B. high fever
C. "hot potato" voice
D. barking cough
A

(u) A. Drooling and a “hot potato” voice are seen with epiglottitis, not viral croup.
(u) B. Fever is usually absent or low grade in patients with viral croup.
(u) C. See A for explanation.
(c) D. Viral croup is characterized by history of an upper respiratory tract symptoms followed by
onset of a barking cough and stridor.

32
Q

A foreign body lodged in the trachea that is causing partial obstruction will most likely
produce what physical examination finding?
Answers
A. stridor
B. aphonia
C. inability to cough
D. progressive cyanosis

A

(c) A. An inspiratory wheeze is called stridor, which indicates a partial obstruction of the trachea
or larynx.
(u) B. Aphonia, inability to cough and progressive cyanosis are seen with complete obstruction of
the trachea, not partial obstruction.
(u) C. See B for explanation.
(u) D. See B for explanation.

33
Q
On physical examination you note diminished breath sounds over the right lower lobe with
decreased tactile fremitus and dullness to percussion. Which of the following is the most
likely cause?
Answers
A. asthma
B. consolidation
C. pneumothorax
D. pleural effusion
A

(u) A. Asthma is characterized by decreased tactile fremitus, but would have resonant to
hyperresonant percussion, not dullness.
(u) B. Consolidation from pneumonia is characterized by dullness to percussion, but would have
an increased, not decreased, tactile fremitus.
(u) C. A pneumothorax is characterized by decreased to absent tactile fremitus, but would have a
hyperresonant percussion note, not dullness.
(c) D. A decreased tactile fremitus and dullness to percussion would be found in a pleural
effusion.

34
Q

A patient with a 15-year history of type 2 diabetic mellitus presents for follow-up. Labs
reveal a BUN 100 mg/dl, serum creatinine 9.2 mg/dl, and serum glucose 164 mg/dl. Which
of the following would you expect to find on physical examination?
Answers
A. Pruritus
B. Hypotension
C. Macroglossia
D. Suprapubic tenderness

A

(c) A. Hypertension, pruritus and xerosis are common findings in the uremic patient.
(u) B. See A for explanation.
(u) C. See A for explanation.
(u) D. Suprapubic tenderness is associated with urinary tract infection or acute obstructive
uropathy.

35
Q
When performing a rectal examination, prostatic massage is contraindicated in
Answers
A. prostatodynia.
B. non-bacterial prostatitis.
C. chronic bacterial prostatitis.
D. acute bacterial prostatitis.
A

(u) A. Prostatodynia is an inflammatory disorder involving voiding dysfunction and pelvic floor
musculature dysfunction. There is no bacterial involvement.
(u) B. Non-bacterial prostatitis is similar to chronic bacterial prostatitis, but no bacteria are
cultured, and the cause is unknown.
(u) C. Prostate massage can be performed in the absence of fever. Expressed prostatic
secretions are cultured to help identify the organism.
(c) D. Vigorous manipulation of the prostate during rectal examination may result in septicemia.
This is contraindicated in the presence of fever, irritative voiding symptoms, and perineal/sacral
pain.

36
Q
Which of the following is typically noted on physical examination in a patient with
diphtheria?
Answers
A. Papular rash on trunk
B. Supraclavicular adenopathy
C. Pharyngeal pseudomembranes
D. Splenomegaly
A

(u) A. See C for explanation.
(u) B. See C for explanation.
(c) C. The classic exam finding noted in diphtheria is a gray pharyngeal pseudomembrane.
Rash, splenomegaly, and supraclavicular adenopathy are not noted in diphtheria.
(u) D. See C for explanation.

37
Q
Cardiac nuclear scanning is done to detect
Answers
A. electrical conduction abnormalities.
B. valvular abnormalities.
C. ventricular wall dysfunction.
D. coronary artery patency/occlusion.
A

(u) A. An EKG is used to determine electrical conduction abnormalities.
(u) B. An echocardiogram is a non-invasive test used to determine valvular abnormalities and wall
motion.
(c) C. Visualization of the cardiac wall can be done with cardiac nuclear scanning. This is done to
determine hypokinetic areas from akinetic areas.
(u) D. Patency or occlusion is assessed with cardiac catheterization (invasive).

38
Q

A 72 year-old male with a new diagnosis of congestive heart failure and atrial fibrillation,
develops episodes of hemodynamic compromise secondary to increased ventricular rate.
A decision to perform elective cardioversion is made and the patient is anticoagulated
with heparin. Which test should be ordered to assess for atrial or ventricular mural
thrombi?
Answers
A. Electrocardiogram
B. Chest x-ray
C. Transesophageal Echocardiogram
D. C-reactive protein

A

(u) A. Electrical conduction will not assess for mural thrombi.
(u) B. A chest x-ray will not visualize the left atria and ventricles to assess for mural thrombi.
(c) C. Transesophageal echocardiography allows for determination of mural thrombi that may
have resulted from atrial fibrillation.
(u) D. C-reactive protein is not going to give you any information regarding thrombi. This test is
used to identify the presence of inflammation.

39
Q

A 64 year-old patient with known history of type 1 diabetes mellitus for 50 years has
developed pain radiating from the right buttock to the calf. Patient states that the pain is
made worse with walking and climbing stairs. Based upon this history which of the
following would be the most appropriate test to order?
Answers
A. Venogram
B. Arterial duplex scanning
C. X-ray of the right hip and L/S spine
D. Venous Doppler ultrasound

A

(u) A. See B for explanation.
(c) B. Given the patient’s long history of type 1 diabetes mellitus the patient most likely has
vascular occlusive disease. Evaluation of arterial blood flow is assessed using the duplex
scanner. X-ray of the L/S spine and right hip while not harmful may give information regarding
bony structures. Venous Doppler ultrasound will not give information of arterial perfusion.
(u) C. See B for explanation.
(u) D. See B for explanation.

40
Q

A 36 year-old male complains of occasional episodes of “heart fluttering”. The patient
describes these episodes as frequent, short-lived and episodic. He denies any associated
chest pain. Based on this information, which one of the following tests would be the most
appropriate to order?
Answers
A. Holter monitor
B. Cardiac catheterization
C. Stress testing
D. Cardiac nuclear scanning

A

(c) A. Holter monitoring is a non-invasive test done to obtain a continuous monitoring of the
electrical activity of the heart. This can help to detect cardiac rhythm disturbances that can
correlate with the patient symptoms. Cardiac catheterization is an invasive procedure done to
assess coronary artery disease. Stress testing and cardiac nuclear scanning are non-invasive
testing maneuvers done to assess coronary artery disease.
(u) B. See A for explanation.
(u) C. See A for explanation.
(u) D. See A for explanation.

41
Q
A patient with a mitral valve replacement was placed post-operatively on warfarin
(Coumadin) for anticoagulation prophylaxis. To monitor this drug for its effectiveness,
what test would be used?
Answers
A. PTT
B. PT-INR
C. Platelet aggregation
D. Bleeding time
A

(u) A. PTT is a reflection of the intrinsic clotting system and is used to monitor heparin
administration.
(c) B. PT-INR is a reflection of the extrinsic and common pathway clotting system. Coumadin
interferes with Vitamin K synthesis which is needed in the manufacture of factors II, VII, IX, X
which are part of the extrinsic clotting pathway.
(u) C. Platelet aggregation tests are utilized to assess platelet dysfunction.
(u) D. Bleeding time is used to assess platelet function.

42
Q

A 26 year-old male complains of intense itching, especially at night and after hot showers,
for the past 4 days. On physical examination he has a few red papules and areas of
excoriation on his volar wrists, between his fingers, and around his waist. Proper
diagnosis should include which of the following tests?
Answers
A. KOH prep
B. Gram stain
C. Skin scraping microscopy
D. Tzanck prep

A

(u) A. A KOH prep would be used to examine for evidence of a fungal infection.
(u) B. A Gram stain would be used for a bacterial infection and would be inappropriate in this
situation.
(c) C. The history and exam is consistent with a scabies infection. Scrapings from the burrows
should be examined for the presence of mites, eggs, and feces.
(u) D. A Tzanck prep would be used to examine for giant multinucleated cells characteristic of a
herpes infection.

43
Q

A 35 year-old female who recently returned from a backpacking trip complains of fatigue,
malaise, fever, chills, and arthralgias. Physical examination reveals a 6 cm annular lesion
with a red border and a clear center on her mid-back. Which of the following laboratory
tests would support your diagnosis?
Answers
A. KOH prep of skin scrapings
B. Blood cultures
C. RAST testing
D. Serologic antibody testing

A

(u) A. Although the skin lesion may resemble a fungal infection, a fungal dermatophyte would not
present with systemic symptoms.
(u) B. Culturing of <i>Borrelia burgdorferi</i> from clinical specimens, with the exception of skin
biopsies at the site of the lesion, have resulted in low yields.
(u) C. RAST testing is utilized in evaluation of allergies and is not indicated in this situation.
(c) D. Most people with Lyme Disease will have a positive serologic test after the first few weeks
of infection and this would support the diagnosis

44
Q
A patient complains of fatigue, tremors, palpitations, and heat intolerance. The thyroid is
diffusely enlarged and firm on palpation. Which of the following laboratory findings is the
most consistent with this presentation?
Answers
A. Low T4
B. Low TSH
C. Decreased bilirubin
D. Normal radionuclide scan
A

(u) A. See B for explanation.
(c) B. The presentation is consistent with hyperthyroidism. Laboratory findings include low TSH,
elevated free and total thyroid hormone levels, and an increased uptake on radionuclide scan.
There may also be elevated bilirubin, liver enzymes, and ferritin levels, along with anemia and
thrombocytopenia.
(u) C. See B for explanation
(u) D. See B for explanation

45
Q
A solitary thyroid nodule is noted on physical examination. The TSH level is normal. The
next step in the evaluation is
Answers
A. measurement of T4 and free T3 levels.
B. a radionuclide thyroid scan.
C. a fine needle biopsy.
D. a surgical excision.
A

(u) A. Measurement of T4 and T3 levels would not be of benefit in the evaluation of a solitary
thyroid nodule with a normal TSH level.
(u) B. A thyroid scan would be the next step if there were a low TSH level.
(c) C. Fine needle aspiration (FNA) is the first step in the evaluation of a solitary nodule with a
normal TSH level. FNA has a high level of accuracy in diagnosing benign versus malignant
nodules in this setting.
(u) D. Surgical excision would be the final step after determination of malignancy or suspicion of
malignancy by FNA.

46
Q

A 32 year-old carpenter complains of right eye irritation all day after driving a metal stake
into the ground with his hammer. He states that “something flew into my eye.” Visual
acuity is 20/20. Pupils are equal, round, reactive to light and accommodation. Extraocular
movements are intact. There is minimal right corneal injection. No foreign body is noted
with lid eversion. Fluorescein stain reveals a tiny pinpoint uptake in the area of the
corneal injection. Which of the following is the most appropriate diagnostic test at this
stage?
Answers
A. MRI
B. X-ray orbits
C. Applanation tonometry
D. Fluorescein angiography

A

(h) A. MRI should never be used when there is suspicion of an iron-containing intraocular foreign
body.
(c) B. Orbital x-rays or CT scan will be most helpful in identifying an intraocular metallic foreign
body.
(u) C. Tonometry is used to evaluate intraocular pressure, but not the presence of intraocular
foreign bodies.
(u) D. Fluorescein angiography is used to evaluate vessels of the eye, not intraocular foreign
bodies.

47
Q

A 45 year-old male complains of loss of hearing in his left ear. He also complains of
ringing in the ear, and has had occasional dizziness. On exam, there is unilateral leftsided
sensorineural hearing loss and a diminished corneal reflex. Neuro exam is
otherwise normal. TMs are normal, and canals are clear. Neck is supple, without
adenopathy. Oropharynx is normal. Of the following, the best diagnostic study to identify
the cause of this patient’s complaints is
Answers
A. auditory brainstem evoked response.
B. gadolinium-enhanced MRI.
C. acoustic reflex testing.
D. vestibular testing.

A

(u) A. See B for explanation.
(c) B. MRI has replaced auditory brainstem evoked response and acoustic reflex testing in the
evaluation of patients for acoustic neuromas.
(u) C. See B for explanation.
(u) D. Vestibular testing is not a useful screening test for acoustic neuromas.

48
Q
Which of the following laboratory abnormalities is most commonly seen acutely in a
patient who has a massive GI bleed?
Answers
A. Increased BUN level
B. Hypercalcemia
C. Hyponatremia
D. Increased AST
A

(c) A. Blood in the gut will cause a considerable increase in the BUN that is independent of
decreased renal perfusion or intrinsic renal dysfunction. BUN rises as a result of catabolism and
absorption of blood protein with a resultant increase in nitrogenous waste.
(u) B. Acute blood loss does not result in a change in the calcium level unless multiple
transfusions are given.
(u) C. Massive GI blood loss acutely results in blood volume contraction without acutely changing
the sodium concentration until intravenous therapy is given
(u) D. Increases in the serum AST is the result of hepatocyte injury or inflammation and does not
occur as a result of GI bleeding.

49
Q
Primary biliary cirrhosis will have which of the following laboratory results?
Answers
A. Decreased haptoglobin
B. Anticholinesterase antibodies
C. Antimitochondrial antibodies
D. Elevated ceruloplasmin
A

(u) A. Haptoglobin is a glycoprotein that is made in the liver that acts as a scavenger molecule to
recapture iron after hemolysis occurs. Its levels decrease with active bleeding or cell destruction
as seen in hemolytic anemia.
(u) B. Anticholinesterase antibodies are evaluated in patients suspected of having myasthenia
gravis.
(c) C. Antimitochondrial antibodies are seen in patients with primary biliary cirrhosis, a chronic,
progressive cholestatic disease of the liver that is characterized by destruction of the extrahepatic
bile ducts.
(u) D. Ceruloplasmin elevations are seen with Wilson’s disease, a disease that is due to a
disordered copper metabolism.

50
Q

Which of the following diagnostic tests is considered to be the best initial test to order in a
patient with suspected gallbladder disease?
Answers
A. Ultrasound
B. Hepatic iminodiacetic acid (HIDA) scan
C. Flat plate of the abdomen
D. Endoscopic retrograde cholangiopancreatography (ERCP)

A

(c) A. Ultrasound of the abdomen is the best test for checking the extra-hepatic biliary tree for
ductal dilatation and choledocholithiasis.
(u) B. HIDA scan is usually ordered to assess gallbladder function. It is mostly ordered if initial
ultrasound is normal and there is still a high index of suspicion for gallbladder disease.
(u) C. Flat plate of the abdomen will only identify about 10 to 15% of gallstones.
(u) D. ERCP is performed to remove gallstones that have become lodged in the common bile
duct. It is not an initial study that is performed.

51
Q

An 8-year-old presents with splenomegaly. CBC results reveal the following: WBC-
6,300/microliter, Hgb- 10.5 g/dl, Hct- 31%, MCV- 87 fL, MCHC- 39 g/dl, MCH- 28 pg, and
platelets- 317,000/mL. Examination of the RBC morphology reveals 80% spherocytes.
Which of the following would be most helpful in confirming the diagnosis?
Answers
A. Direct Coombs test
B. Osmotic fragility
C. G-6-PD level
D. Serum ferritin

A

(u) A. The direct Coombs test would be negative and would not be helpful in diagnosing
hereditary spherocytosis.
(c) B. Hereditary spherocytosis presents with a normocytic, normochromic anemia and many
spherocytes. Diagnosis is confirmed with a positive osmotic fragility test.
(u) C. G-6-PD deficiency presents with minimal or no RBC morphologic abnormalities and is
diagnosed by measuring G-6-PD enzyme activity level.
(u) D. Iron deficiency anemia typically presents with microcytic, hypochromic red blood cells and
is diagnosed with a serum ferritin.

52
Q

What test is the single most useful test in establishing the diagnosis of multiple sclerosis?
Answers
A. Cerebral spinal fluid cell count and protein level
B. Cerebral spinal fluid immunoglobulin studies
C. Evoked potentials
D. Magnetic Resonance Imaging

A

(u) A. While cerebral spinal fluid cell count, protein levels, and immunoglobins may be abnormal
they are not specific for multiple sclerosis.
(u) B. See A for explanation.
(u) C. Evoked potentials are most useful in the detection of subclinical involvement of
neuropathways in MS, but does not establish the diagnosis.
(c) D. The presence of plaques on MRI is a key finding in establishing the diagnosis of MS.

53
Q

A 22 year-old male presents to the clinic complaining of excessive daytime somnolence
and strong desires to sleep at inappropriate times. He came in today because he had an
episode of “feeling paralyzed” as he was falling asleep yesterday. What is the most
appropriate diagnostic test to confirm this patient’s diagnosis?
Answers
A. MRI of the brain
B. Electroencephalogram
C. Multiple sleep latency test
D. Overnight polysomnography

A

(u) A. See C for explanation.
(u) B. See C for explanation.
(c) C. Multiple sleep latency test is required to observe the abrupt transition to REM sleep and
establish the diagnosis of narcolepsy.
(u) D. See C for explanation.

54
Q

A 25 year-old female presents with vulvar pruritus and a thick, white vaginal discharge.
Which of the following tests will be most helpful in making the correct diagnosis?
Answers
A. KOH prep
B. Gram stain
C. Tzanck smear
D. FTA-ABS

A

(c) A. KOH prep is used to assist in the diagnosis of vaginal candidiasis, which presents with
vulvar pruritus and white curd like, cheesy vaginal discharge.
(u) B. Gram stain is used in the diagnosis of bacterial infections.
(u) C. Tzanck smear is used to diagnose herpes infections.
(u) D. FTA-ABS is used to diagnose syphilis.

55
Q
A 25 year-old presents with pelvic pain and uterine bleeding. Her Beta-HCG was 1200
mIU/L six days ago. Her current Beta-HCG is 1600 mIU/L. What is the next best test in the
evaluation of this patient?
Answers
A. Laparoscopy
B. Culdocentesis
C. Dilation and curettage
D. Transvaginal ultrasound
A

(u) A. The use of laparoscopy in the diagnosis of an ectopic pregnancy has decreased, but is still
useful when a definitive diagnosis is difficult.
(u) B. Culdocentesis is used in the diagnosis of intraperitoneal bleeding, which may or may not be
present in an ectopic pregnancy.
(u) C. Dilation and curettage may confirm or exclude intrauterine pregnancy but is not the next
best test in the evaluation of ectopic pregnancy.
(c) D. Transvaginal ultrasound is the best test to separate ectopic from intrauterine pregnancy.

56
Q

A couple presents having not been able to conceive over the past 12 months. Evaluation
of the male has been normal. The female has had regular menses. Ovulation can be
confirmed with mid-luteal phase measurement of which of the following?
Answers
A. Thyroid stimulating hormone
B. Luteinizing hormone
C. Progesterone
D. Prolactin

A

(u) A. TSH is used only if signs of thyroid disease are present.
(u) B. LH, FSH, and prolactin are used to confirm ovulation in patients with irregular menstrual
cycles.
(c) C. Ovulation can best be confirmed by measuring serum progesterone levels in the mid-luteal
phase.
(u) D. See B for explanation.

57
Q

A 65 year-old female presents to the office with a six-month history of back pain. The
patient states that she is shrinking and thinks she is about an inch shorter than she was a
year ago. Serum parathyroid hormone, calcium, phosphorus, and alkaline phosphatase
are all normal. Which of the following would you most likely see on the x-ray of her spine?
Answers
A. Radiolucent lesions
B. Demineralization
C. Chondrocalcinosis
D. Subperiosteal resorption

A

(u) A. Paget’s disease of bone presents with bone pain, kyphosis, bowed tibias, large head, and
deafness. The initial lesions are destructive and radiolucent. Paget’s disease has a normal
serum calcium and phosphate, but the serum alkaline phosphatase is elevated.
(c) B. Osteoporosis presents with varying degrees of back pain and loss of height is common.
The serum calcium, parathyroid hormone, phosphorus, and alkaline phosphatase are normal. Xray
findings demonstrate demineralization in the spine and pelvis.
(u) C. Chondrocalcinosis is the presence of calcium-containing salts in articular cartilage and is
commonly seen in hyperparathyroidism, diabetes, hypothyroidism, and gout.
(u) D. Hyperparathyroidism is frequently asymptomatic. Serum parathyroid hormone and serum
calcium are elevated. X-ray findings include demineralization, subperiosteal resorption of bone
especially in the radial aspects of the fingers.

58
Q

In a trauma patient who has a suspected cervical spine injury, the x-ray view that will
identify the majority of significant injuries is
Answers
A. lateral.
B. oblique.
C. anteroposterior.
D. odontoid.

A

(c) A. The lateral view shows 70-80% of significant injuries. It is important to visualize all seven
cervical vertebrae and the upper margin of T1 to avoid missing possible pathology.
(u) B. The oblique view is usually not included in the initial set of x-rays taken. Bilateral supine
oblique is a view that may be ordered if all seven cervical vertebrae are not seen on the lateral
view.
(u) C. Anteroposterior view shows

59
Q

A 38 year-old male sustained a fracture of the left distal tibia following a 25-foot fall and is
taken to the operating room for an open reduction internal fixation of the distal tibia.
Sixteen hours post-op, the patient develops sustained pain, which is not relieved with
narcotics. On passive range of motion of the toes the patient “yells” in agony. The patient
also states that the top of his foot has decreased sensation. On physical examination the
physician assistant notes that the leg is swollen and the foot is cool to touch. Based upon
this information what diagnostic testing should be done?
Answers
A. X-ray of the lower leg and ankle.
B. Doppler studies.
C. Bone scan.
D. Compartment pressure

A

(u) A. X-rays of the lower leg and ankle will only determine bone placement.
(u) B. Doppler studies will confirm the presence of a decreased pulse.
(u) C. A bone scan is not indicated in the evaluation of compartment syndrome.
(c) D. Compartmental pressures should be obtained as soon as possible. If they are elevated this
is a surgical emergency.

60
Q

A 19 year-old female presents with complaints of intermittent abdominal pain associated
with recent, frequent episodes of regurgitation of food for the past several months and
worsening over the past 12 hours. She maintains a normal weight for her height however
she seems obsessed with losing weight. On examination the physician assistant notes
multiple dental caries, bilateral tenderness of the parotid glands and mild epigastric
tenderness. Which of the following findings would you expect to find on laboratory tests
to support your suspected diagnosis?
Answers
A. hypokalemia
B. hypocalcemia
C. hyperchloremia
D. hypermagnesemia

A

(c) A. This patient most likely has bulimia nervosa - purging type. Self-induced vomiting is the
most common method of purging and this is supported by the physical examination findings noted
in this patient. Laboratory findings to support this diagnosis include hypochloremia with
subsequent hypokalemia due to renal compensatory mechanisms, hypomagnesemia and
metabolic alkalosis.
(u) B. See A for explanation.
(u) C. See A for explanation.
(u) D. See A for explanation.

61
Q

A divorced female patient presents for an employment physical. She states she has had a
“run of bad luck” with jobs and has not been able to hold any job for longer than 2-3
months. She also states she has been arrested several times for getting into fights when
she is out with the girls. She states she drinks an occasional beer, but denies any
significant problems with alcohol. Which of the following laboratory findings would
support your suspected diagnosis?
Answers
A. decreased triglycerides
B. decreased serum uric acid
C. increased LDL cholesterol
D. increased mean corpuscular volume

A

(u) A. See D for explanation.
(u) B. See D for explanation.
(u) C. The primary lipid abnormalities demonstrated with alcoholism are increased triglycerides
and increased HDL cholesterol, not LDL cholesterol.
(c) D. This patient most likely has alcohol abuse as evidence by her social, occupational and legal
issues. Laboratory tests will reveal the presence of an elevated mean corpuscular volume,
triglycerides, serum uric acid and liver function tests.

62
Q
Which of the following is essential to make a diagnosis of cystic fibrosis?
Answers
A. Positive family history
B. Elevated sweat chloride
C. Recurrent respiratory infections
D. Elevated trypsinogen levels
A

(u) A. Cystic fibrosis is a genetic disease, but a positive family history in and of itself is not
enough to diagnose the condition.
(c) B. The diagnosis of cystic fibrosis is made only after an elevated sweat chloride test or
demonstration of a genotype consistent with cystic fibrosis.
(u) C. While recurrent respiratory infections are a classic presentation of cystic fibrosis, the
diagnosis relies on confirmation, as noted in explanation B.
(u) D. Trypsinogen levels are used as a neonatal screening test and if elevated should be
followed by more definitive testing to confirm the diagnosis.

63
Q
An adult patient who is HIV positive receives a PPD. He develops an area of induration
that measures 8 mm after 48 hours. Which of the following is the most appropriate
interpretation of this test result?
Answers
A. positive
B. negative
C. active infection
D. falsely negative
A

(c) A. A reaction size of greater than or equal to 5 mm in a HIV positive patient is considered a
positive tuberculin skin test reaction.
(u) B. See A for explanation.
(u) C. A positive PPD identifies patients that have been infected with Mycobacterium tuberculosis,
but does not indicate whether the disease is currently active or inactive.
(u) D. See A for explanation.

64
Q

A 23 year-old female with history of asthma for the past 5 years presents with complaints
of increasing shortness of breath for 2 days. Her asthma has been well controlled until 2
days ago and since yesterday she has been using her albuterol inhaler every 4-6 hours.
She is normally very active, however yesterday she did not complete her 30 minutes
exercise routine due to increasing dyspnea. She denies any cough, fever, recent
surgeries or use of oral contraceptives. On examination, you note the presence of
prolonged expiration and diffuse wheezing. The remainder of the exam is unremarkable.
Which of the following is the most appropriate initial diagnostic evaluation prior to
initiation of treatment?
Answers
A. chest x-ray
B. sputum gram stain
C. peak flow
D. ventilation – perfusion scan

A

(u) A. A chest x-ray should be ordered in an asthmatic patient only if you are concerned about the
presence of pneumonia or pneumothorax, neither of which is supported by the H&P findings
noted above.
(u) B. A sputum gram stain is performed in patients who you suspect have an infectious process,
such as pneumonia.
(c) C. A peak flow reading will help you to gauge her current extent of airflow obstruction and is
helpful in monitoring the effectiveness of any treatment interventions.
(u) D. A ventilation-perfusion scan (V/Q scan) is indicated in cases of suspected pulmonary
embolism. The patient above does not have any risk factors that would lead you to suspect such
a diagnosis.

65
Q

A patient presents with a history of progressive worsening of dyspnea over the past
several years. He gives a history of having worked as a ship builder for over 50 years. He
denies any alcohol or tobacco use. On examination you note clubbing and inspiratory
crackles. Which of the following chest x-ray findings support your suspected diagnosis?
Answers
A. hyperinflation and flat diaphragms
B. interstitial fibrosis and pleural thickening
C. cavitary lesions involving the upper lobes
D. “eggshell” calcification of hilar lymph nodes

A

(u) A. Chest x-ray findings of hyperinflation and flat diaphragms suggest long-standing chronic
obstructive lung disease.
(c) B. This patient most likely has asbestosis, which is supported by his occupation as a ship
builder and clinical presentation as noted above. Chest x-ray findings include interstitial fibrosis,
pleural thickening and calcified pleural plaques on the diaphragm or lateral chest wall.
(u) C. Chest x-ray findings of cavitary lesions involving the upper lobes suggest pulmonary
tuberculosis.
(u) D. Chest x-ray findings of “eggshell” calcification of hilar lymph nodes strongly supports the
diagnosis of silicosis.