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Immunology > 1&2 > Flashcards

1&2 Flashcards

1
Q

Name cellular proteins that inhibit viral infection

A

TRIM
APOBEC3
Tetherin

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2
Q

Name antimicrobial proteins

A

Defensins (α and β)
Cathelicidins
Histatins

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3
Q

Name soluble PRRs

A

Pentrexins (CRP)
Collectins
Ficolins
Complement proteins

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4
Q

Name cell surface PRRs

A

C-Type lectins
TLR 2,4,5
Scavenger receptors on phagocytes

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5
Q

Name endosome/phagosome PRRs

A

TLR3,7,8,9

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6
Q

Name cytosolic PRRs

A

NLRs
RIG-like receptors
c-GAS

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7
Q

Name 3 classes of cytosolic receptors

A

NLRs
RLRs
c-GAS/STING

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8
Q

Name enzymes that damage microbial walls

A 
Cathepsin G
BPI (bac permeability i)
Lysozome
Lactoferrin
Proteolytic enzymes
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9
Q

What cell releases IFNγ

A

NK

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10
Q

What causes apoptosis?

A 
FasL binds to Fas—> activates FADD
FADD->
Procaspase-8->
Caspase-8->
Caspase-3 inactive->
Caspase-3->
APOPTOSIS
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11
Q

What do DCs express?

A

CCR7

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12
Q

Name pro-inflammatory cytokines

A

TNF-α
IL-6
IL-1β

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13
Q

Name anti-inflammatory cytokines

A

TGFβ

IL-10

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14
Q

What do tissue mast cells respond to?

A

C3a
C5a
PAMPs
DAMPs

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15
Q

What do mast cells release?

A

Histamine
Cytokines
Chemotactic factors

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16
Q

Which cytokines (from PRR activation) act to increase liver secretion of APPs?

A

IL-1
IL-6
TNF

17
Q

Name some APPs

A

C3
C-reactive protein
Fibrinogen

18
Q

What do tissue macrophages release?

A

Cytokines:
TNF
IL-6
IL-1β

19
Q

Name inflammatory mediators released by tissue macrophages

A

Leukotreines

Prostaglandins

20
Q

What does phosphatidyl serine cause Mφ to release?

A

Anti-inflammatory cytokines:
IL-10
TGFβ

21
Q

What receptors are needed for extravasation?

A

P-selectin on endothelium
PSGL-1 on neutrophils

Integrins ICAM-1, VCAM-1 on e
LFA-1, VLA on n

22
Q

What induces Integrins expression on endothelium?

A

TNF
IL-1
LPS

Immunology (16 decks)

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