1 Flashcards
Ddx for 1st trimester bleeding
SAB
Postcoital bleeding
Ectopic pregnancy
Vaginal or cervical lesions or lacerations
Extrusion of molar pregnancy
Non pregnancy cause of bleeding
What are the 3 classes of leiomyomas (fibroids)?
Submucosal
Intramural
Subserosal
What is the most common type of leiomyoma?
Intramural
What type of leiomyoma is most commonly associated with heavy or prolonged bleeding?
Submucosal
Risk factors for leiomyomas
AA heritage
Nonsmoking
Increased estrogen exposure (Early menarche, Nulliparity, Perimenopause)
Increased EtOH use
HTN
What is the most common sx of leiomyomas?
Abnormal uterine bleeding (AUB)
Biannual exam for leiomyomas can often reveal…
A nontnder irregularly enlarged uterus
Do fibroids shrink with hormonal tx?
GnRH is the only hormone to decrease size. However, once any tx is stopped the fibroid will continue growing.
Endometrial hyperplasia can occur through what pathogenesis?
Unopposed estrogen
Endometrial hyperplasia is the abnormal proliferation of what elements of the endometrium?
Glandular and stromal elements
What causes the increased risk for endometrial hyperplasia?
Unopposed estrogen exposure
Tx for simple and complex hyperplasia with out atypia is …
Progestin therapy
Tx for endometrial hyperplasia with atypia
Hysterectomy
Most common sites of endometriosis
Ovary and pelvic peritoneum
What are 4 theories about the etiology of endometriosis
Lymphatic system
Metaplastic transformation
Retrograde menstruation
Altered immune system
Risk factors for endometriosis
Increased estrogen exposure (Nulliparity, Early menarche, Prolonged menses)
Mullerian anomalies
First degree relatives
Autoimmune disorders
Sx of endometriosis
Cyclic pelvic pain
Dysmenorrhea
Dyspareunia
AUB
Bowel and bladder sx
Subfertility
DDX of endometriosis
Chronic processes that result in recurring pelvic pain
Infection
PID
Interstitial cystitis
Masses
Ovarian mass
Final ovarian cysts
Adenomyosis
IBS
Pelvic adhesions
Ectopic
Ovarian neoplasms
Tx for endometriosis
NSAIDs
Estrogen-progestin contraceptives
Progestin
GnRH agonists
Aromatase inhibitors
Surgery if fertility is not wanted
Adenomyosis
Extension of endometrial tissue into the uterine myometrium
Tx of Adenomyosis
Progestin containing IUD and hysterectomy
Adenomyoma
Well-circumscribed non-encapsulated collection of endometrial tissue with the uterine wall
Difference in Adenomyosis and leiomyoma
Adenomyosis - endometrial tissue into the myometrium
Leiomyoma - proliferation of smooth muscle cells within the myometrium
Why does adenomyosis not respond to hormone tx?
Does not contain glandular and stromal endometrial tissue. Extends from the basal is layer.
Adenomyoma
Well-circumscribed non-encapsulated smooth muscle cells and endometrial glands and stroma.
Most effective temporary management of adenomyosis
Levonorgestrel-containing IUD
Risk factors for endometritis
Retained products
STIs
Intrauterine foreign bodies/instrumentation
Risk factors for PID
Age 15-25
Non-white and non-Asian
Multiple partners
Recent douching
PID
Smoking
IUD with chlamydial/gonorrhea
What 2 organisms are suspected to cause 40% of PID?
N. Gonorrhoeae and C. Trachomatis
What three components can an ovarian tumor be associated with?
Surface epithelium
Ovarian germ cells
Ovarian stroma
What is the most common type of ovarian tumor?
Epithelial tumors
What are the most common lymph nodes to be involved in ovarian cancer spread?
Retroperitoneal pelvic lymph nodes
Para-aortic lymph nodes