1 Flashcards
Which type of microneedles don’t have to be removed after application
Dissolving microneedles
What type of vaccine can benefit from delivery system
Subunit vaccine
Which nanoparticles type/s is/are made of amphiphilic molecules
Liposomes
Nanoparticle made of a polymer with many branches
Dendrimers
What’s the size of a dendrimers
1.5-10nm
Microsphere, Microparticles
•can be solid microparticales
Porous microspheres
Hollow in nature microcapsules
•spherical
•made from lipids , polymers , protiens etc
•size 1 - 1000 micro
• PLA /PLGA mostly in market
What’s the mechanism controlling drug release of incorporated drug in Microspheres
Degradation rate of matrix in vivo
Which type of contruct have an EPR effect
•polymer-drug conjugates: dendrimers
•protein nanoparticles
•polymeric nanoparticles
Micro capsules (no)
Stealth nanoparticles
•solid polymeric nanoparticles coated with PEG on surface
•Hydrophilic surface
•less recognized by immune system
•prolonged half life
•Inc plasmas circulation time ,
Inc accumulation at leaky site
•less accumulated in liver and spleen
•achieve active targeting by attaching targeting groups on nanoparticles
Quality control dissolution test
•Used to Verify safety and efficacy
•over discrimantory methods are sometimes chosen
•surfactants are not always added:
-in reciprocating cylinder USP apparatus 3 : can’t be added
-in sink condition, added in conc above the CMC “Critical micelle conc”
•sink conditions are generally used
•they are simpler than predictive test
•they do not simulate closely the physiological conditions in the stomach and intestines,
Abraxane, albumin-based nano particles formulation containing paclitaxel/taxol
•Inc the overall solubility of the system
Low solubility
•PREVIOUS FORMULATION: solvent (cremophor) a highly toxic castor oil derivative
Abraxane: avoids the toxicity when used with taxol
•abraxane used for treatment of breast cancer
•it accumulates in cancer tissue by active and passive targeting
PEGylated protiens advantages and disadvantages
Advantages:
•improve drug delivery ( prolonged half life and less enzymatic degradation)
•low toxicity
•high hydration higher solubility
•ease of use of conjugation with drugs
Disadvantages:
•when it’s conjugated with protien therapeutics, activity can be reduced
Subcutaneous and intramuscular administration of liposomes can?
Target drug to reach lymphatic system, lymph nodes (B, T and other immune cells)
Ambisome , liposomal formulation of Amphotericin B
•given IV
•in bilayer of liposomes
• they are SUV “small unilamellar vesicles” 80nm
•poorly soluble
•enable to reduce high risk of nephrotoxicity ,associated with Amphotericin B (when not formulated to liposomes)
Sustained release liposomes
•MVV(100nm to several micrometers)
“multi vesicles liposomes”
•epidural administration
•multiple bilayers
•slow breakdown and slow clearance controlling the drug release
•form a depot in site of injection