1 Flashcards
Give the shared effect of beta blockers and non-dihydropyridine calcium antagonists on the heart (2)
decrease myocardial contractility
decreases HR
Name one renin inhibitor and one aldosterone antagonist
Aliskerin - renin inhibitor
Spironolactone - aldosterone antagonist
Mechanism of action of reserpine
Binds tightly and irreversibly to adrenergic storage vesicles in central and peripheral adrenergic neurons by interfering with vesicular membrane-associated transporter (VMAT)
2 most important adverse metabolic effects common to both propranolol and hydrochlorothiazide
increases insulin resistance/decreases glucose tolerance
increases cholesterol levels
this drug may cause hypertrichosis
minoxidil
beta blocker indicated for heart failure
carvedilol
important indication of cardioselective beta blockers aside from hypertension
CHF, MI
mechanism of action of minoxidil
hyperpolarization of cells through increased K efflux by activating ATP-dependent potassium channels
site of action of thiazide diuretics
distal convoluted tubule
name 1 short acting ACE inhibitor
captopril
shortest acting beta blocker
esmolol
why do we give a1 blockers like prazosin before bedtime
orthostatic hypotension
enzyme in rbc that converts cyanide to thiocyanate
rhodanase
CO, TPR or BOTH
hydrochlorothiazide
nifedipine
minoxidil
metoprolol
both (diuretic)
tpr (ccb)
tpr (K+ ATP channel opener)
co (bb)
contraindication of ACEi and ARBs in pregnancy
pulmonary hypoplasia
