1-100 Flashcards
what makes an aortic dissection “Complicated”
Complicated dissection is those with:
- persistent pain
- thoracoabdominal mal perfusion
- impending rupture
sizing of the graft for a valve-sparing root
- Estimated annulus
- Dacron graft size
Aortic annulus ~ 2/3 cusps height x 2
Dacron graft ~ 2/3 cusps height x 2 + LVOT thickness
DeBakey type 1 aneurysm
Ascending and descending aorta
Signs of mitral stenosis
- Low volume pulse pressure
- Irregular pulse
- Tapping non-displaced apex beat
- Loud S1 heart sound
- Opening snap Mid diastolic rumbling heart loudest at the apex
- Pulmonary HTN
- Mitral facies : Rosy cheeks while the rest of the face is cyanotic
- Central cyanosis
- Loud P2 heart sound
- TR – pan systolic murmur at right sternal edge
- Pulmonary Regurgitation: Grahm Steel early systolic murmur on inspiration
Social history questions for aortic dissection
physical exam
Query the use of amphetamines or coccaine
Physical:
Skeletal to diagnose CT disease
Vascular exam should be documented
Medical treatment of a type B dissection
a. Beta - blocker ( esmolol or labetolol)
b. vasodilator (nipride)
what territory does ECG lead I represent
anterolateral
Severe mitral regurgitation in an asymptomatic patient direction
of treatment
- if LVEF > 60, LVESD < 40 and liklihood of repair > 95% with expected mortality < 1% –> Repair
- if new onset afib or PASP > 50 and liklihood of repair > 95% and expected mortality < 1% –> Repair
- if LVEF 30-60% or LVESD > 40 –>“mitral surgery”
Per Boling:
LVEF < 60%, PAP > 50, LVESD > 40, AF
If > 95% repair, <1%, mortality
MVA for Moderate MS
MS (mitral valve area 1.6 cm2 to 2.0 cm2)
the direction of the jet with a restricted leaflet
jet will be toward the restricted leaflet
Ghent criteria
Minor Skeletal Criteria
- Pectus excavatum of moderate severity
- Joint hypermobility
- Highly arched palate with crowding of teeth
- Facial appearance:
- dolichocephaly
- malar hypoplasia
- enophthalmos
- retrognathia
- down-slating palpebral fissures
Low Risk Pulmonary Embolism
Embolism without the presence of :
- shock
- hypotension
- RV dysfunction
- Myocardial injury
Diagnostic criteria for STEMI
Angina sx for > 20 min
with
ST elevation > 1mm in 2 contigous leads
or
LBBB
Method of selecting a tricuspid ring size
- Using a sizer:
septal leaflet and the surface area of leaflet tissue from the anterior pap muscle
- Approximately
30-32 for a female
32-34 for a male
Reccomendation
Mitral stenosis patient
symptomatic
MVA < 1.5cm2
Wilkins < 8
No LA thrombus
No MR
Class 1: PMBC
Anteroseptal ECG leads
V1 and V2
IIb/IIIa inhibitors
when should they be discontinued
- Eptifibatide (integrillin) - IIb/IIIa Inhibitor - 2-4 hr
- Tirofiban ( Aggrastat) - IIb/IIIa inhibitor -2 -4 hours
- Abciximab (Repro) - IIb/IIIa inhibitor -12 hours
EAT !
Crawford Type IV aneurysm
Extends from the diaphragm to below the renal arteries
what territory does V6 represent?
anterolateral
Ghent Criteria
Pulmonary minor criteria
Spontaneous PTx
Apical Blebs
Type B aortic dissection -
Medical vs Surgical management
what is the rate of surgical reintervention
Equivalent
Fondaparinux trade name
Arixtra
Ghent criteria
minor skin criteria
- Strech marks not associated with weight changes
- Recurrent incisional hernia
Ghent Criteria:
Major family history Criteria
- Having a first-degree relative (parent, child, or sibling) who meets these diagnostic criteria independently
- Presence of a mutation in FBN1 known to cause the Marfan syndrome
- Presence of a haplotype around FBN1, inherited by descent, known to be associated with unequivocally diagnosed Marfan syndrome in the family
Posterior medial papillary muscle
blood supply
PM pap muscle is more vulnerable because of its single blood supply:
RCA for right dominant
cx for left dominant
DeBakey IIIa aneurysm
Confined to the thoracic descending aorta alone
“theme” of fibroelastic defficiency mitral repair
No resection or limited resection
which ECG lead is the ground?
Right Leg
Ghent Criteria
Minor CV Criteria
- Mitral valve prolapse with or without mitral valve regurgitation
- Dilatation of the main pulmonary artery, in the absence of valvular or peripheral pulmonic stenosis or any other obvious cause in patients age < 40 years
- Calcification of the mitral annulus in patients age < 40 years
- Dilatation of dissection of the descending thoracic or abdominal aorta in patients age < 50 years
“theme” to Barlow’s repair
Barlow’s - remove tissue
Tissue dissection and leaflet displacement
General criteria for Marfan’s Diagnosis by Ghent
Positive family history
- at least 2 systems (skeletal, cardiovascular, ocular)
- and the presence of at least 1 major criterion (eg, ascending aortic aneurysm, ectopia lentis)
negative family history / unknown__,
major criteria in 2 systems and have involvement of at least 1 other system (skeletal, cardiovascular, ocular).
Ghent Criteria
Major Skeletal Diagnostic Criteria
Presence of at least 4 :
- Pectus carinatum
- Pectus excavatum requiring surgery
- Reduced upper-to-lower segment ratio or arm span-to-height ratio greater than 1.05
- Wrist and thumb signs
- Scoliosis > 20 degrees or spondylolisthesis
- reduced extensions at the elbows (< 170 degrees) Medial displacement of the medial malleolus causing pes planus
- Protrusio acetabulare of any degree (ascertained on radiographs) (femoral head is medial to the ileoischeal line)
The goal of a medical therapy for a type B dissection
Reduction of the Systolic bp
Reduction of the mean bp
Reduction of the dp/pt
how long should a BMS be on plavix
30 days
What is the Crawford Extent:
Descending aorta from near the left subclavian to the abdominal vessels but not the renal arteries
Type I
Anterio apical ECG leads
V3 - V4
In repairing a descending aneurysm
what should be done with intercostal arteries above T7?
Why?
Oversew
Eliminate steal of blood from the spinal cord
ECG of PE
Lead 3 findings
- q-wave
- inverted t-wave
Factors which make a patient more susceptible to recurrent MR
- larger MV annular diameter (>3.7cm)
- High tethering area
- greater MR severity (3.5+)
anterolateral ECG leads
V5-V6, I, avL
duration of symptoms for STEMI
20 minutes
Evaluation of IMR
- features to note on the evaluation of the angiogram
- look for an occluded vessel with an inferior wall motion abnormality
- Clarify right vs left dominance
- Viability may be of help
The phenotype of fMR with normal mitral leaflets
- Pronounced global LV dilation
(typically have < 30% EF)
2.Ischemic MR - frm caused by asymmetric LV remodeling
disruption of the subvalvular apparatus (of the posterior medial papillary muscle leading to leaflet tethering)
what territory does ECG lead V4 represent?
anteroapical
what territory does ECG lead V3 represent
anteropical
Wilkins Score
Wilkins Score:
- Components:
- Leaflet mobility
- Thickenening
- leaflet calcification
- subvalvular thickening
- Each scores between 0-4 - (score between 0-16)
- > 9 – unlikely to be amenable to PMBV
Crawford type II aneurysm
Descending aneurysm that
Begins: near the subclavian
Extends: below the renal arteries
how long should a DES be on plavix
1 year
Diastolic pressure half time for mitral stenosis
> 150ms (severe)
> 220 ms (very severe)
The primary goals of repairing a type B dissection
To replace only a short segment of aorta
To redirect flow into the true lumen
To stay above T7 and avoid reimplant of intercostal arteries
what territory does ECG lead III represent
Inferior
what territory does ECG lead aVL represent
anterolateral
Defect associated with Ehlers-Danlos syndrome
Defective type III Callogen
the hallmark of this disease is Aortic Dissection, not an aneurysm
What leads suggest right ischemia
II, III, aVF
+/-
reciprical changein V1 V2
DeBakey Type 2 aneurysm
Ascending alone
Intermediate risk pulmonary embolism
Embolus in the RV +/- evidence of myocardial injury shock or hypotension
DeBakey IIIb aneurysm
Thoracic aorta
and
abdominal aorta
Rx for low risk PE
LMWH or Fondaparinux
Fondaparinux dosing
weight based
50-100Kg –> 7.5,
>100kg: 10mg
give sc x 5-9 days –> overlap with coumadin
Dc with INR 2-3
hold if plt < 100,000
Rx for intermediate risk pe
Heparin / Fondaparinux and long-term A/C
ECG leads indicative of inferior wall damage
II, III, aVf
what territory does V5 represent
anterolateral
Class IIa reccomendations for percutaneous balloon mitral commisurotomy
Class IIa
- asymptomatic patients
- very severe MS (mitral valve area ≤1.0 cm2, stage C)
- favorable valve morphology
- the absence of left atrial thrombus or moderate-to-severe MR
Mitral Regurgitation
Recommendation directly for repair
IIa:
- Severe MR on echo
- Asymptomatic with either:
- LVEF >60% and LVESD < 40mm
- or
- new AF or PASP > 50 mmHg
- with the likelihood of:
- successful repair > 95%
- and
- expected mortality < 1%
what territory does lead aVf represent
inferior
ECG of PE
lead 1 findings
S-wave
ECG changes indicative of posterior wall infarct
reciprocal changes in V1 and V2
what separates a chronic and acute dissection
14 days
Ghent Criteria
major ocular criteria
Ectopia lentis
Type B Dissection
30 day mortality for
Medical vs Surgical management
Type B 30 day mortality:
Medical management: 9- 16%
Surgical managment: 27-32%
Anticoagulation reccomended for mitral stenosis
Class I Evidence:
1) MS and AF (paroxysmal, persistent, or permanent)
2) MS and a prior embolic event
3) MS and a left atrial thrombus
gastrointestinal bleeding from angiodysplasia in the presence of aortic stenosis.
Heyde’s syndrome is a syndrome of gastrointestinal bleeding from angiodysplasia in the presence of aortic stenosis.
what territory does ECG lead II represent
inferior
Crawford Type III aneurysm
Begins at T6, and extends to the abdominal aorta
what are the class 1 recomendations to perform MVR for MS as concominant surgery
Concominant mitral valve surgery with severe MS (MVA < 1.5cm2) and underoing surgery for other indications.
Ghent Criteria
Minor Occular Criteria
Abnormally flat cornea (as measured by keratometry) Increased axial length of globe (as measured by ultrasound)
Ghent Criteria for Marfan’s
Major cardiovascular criteria
Dilatation of the ascending aorta with or without aortic regurgitation and involving at least the sinuses of Valsalva or dissection of the ascending aorta
Ghent Criteria for Marfan’s Major
Dural Criteria
Lumbarsacral dural ectasia as demonstrated by CT or MRI
Diagnosis with nSTEMI
Chest pain at least 10 minutes
elevated biomarkers
or
ST of 0.5 or 1mm
or
ST depression > 0.5
or
TWI greater than 1mm
Crawford Extent
Begins near the origin of the left subclavian
Extends to below the renal arteries
Type II
MVA for severe Mitral stenosis
< 1.5 cm2 (severe)
<1.0cm2 (very severe)
Ghent Criteria
what systems have major criteria
- Genetics
- Skeletal
- Occular
- CV
- Dura
DeBakey Type III aneurysm
Descending alone
Imaging studies pre CPB
- if the history of a stroke: head CT
- Carotid duplex: if a stroke or bruit or LM
- ABI
- PFT
- Chest CT for any patient with calcification on CT
what territory does V2 represent
Either:
Antero septal
or
reciprocal changes represent posterior
pH Stat or alpha-stat for DHCA
dependent upon the age of the patient:
pH-stat in the paediatric (P in the P)
alpha-stat in the adult patient. (a for the a)
Class 1 Reccomendations for Percutaneous mitral balloon commissurotomy
Class 1 Recommendation:
- symptomatic
- severe MS (mitral valve area ≤1.5 cm2, stage D)
- favorable valve morphology
- the absence of left atrial thrombus
- absence moderate-to-severe MRs )
Class IIb Reccomendations for percutaneous balloon mitral commisurotomy
Class IIb
- asymptomatic patients
- severe MS (mitral valve area ≤1.5 cm2, stage C)
- favorable valve morphology
- absence of left atrial thrombus or moderate-to-severe MR
- asymptomatic patients
- who have new onset of AF.
- Symptomatic
- mitral valve area greater than 1.5 cm2
- evidence of hemodynamically significant MS
- pulmonary artery wedge pressure greater than 25 mm Hg or
- mean mitral valve gradient greater than 15 mm Hg during exercise
- Severely symptomatic (NYHA class III to IV)
- severe MS (mitral valve area ≤1.5 cm2, stage D)
- have a suboptimal valve anatomy and who are not candidates for surgery or at high risk for surgery.
Pre CPB Review of systems (6)
- Stroke
- Renal disease
- Respiratory problems
- Bleeding Disorders
- Peripheral vascular Disease
- Intestinal angina
5-year survival after repair of:
- Ascending
- Arch
- Descending
- Thoracoabdominal
- Marfans
5-year survival after repair of:
- Ascending: 70%
- Arch: 80%
- Descending: 60%
- Thoracoabdominal: 60%
- Marfans: 85%
Reccomendation for
Mitral Stenosis patient
severely symptomatic (NYHA III to IV)
MVA < 1.5cm2
prior failed PMBC
Class 1 Recomendations are to perform surgery
DeBakey classifications including the ascending aorta
Type I and Type II
Labs to order pre CPB
- CBC
- BMP
- Coags
- LFT’s
EKG of Pulmonary Embolism
S1Q3T3
Type B Aortic Dissection:
Factors which would advocate for endovascular treatment
Endovascular -
- Older
- Poor operative risk
- Renal failure
- COPD
- Poor cardiac function
- Acidotic from mal perfusion
- Favorable anatomy
what territory does V1 represent
Either:
Antero septal
or
reciprocal changes represent posterior
MOA of Fondaparinux
chemically related to LMW heparin
Crawford extent I aneurysm
Descending aorta from near the left subclavian to the abdominal vessels but the renal arteries are excluded.
Crawford Extent
Does Type III include the renal arteries
Type III :
From T6 to below the renal arteries.
how do differentiate on physical exam an acute VSD from an MR
MR is best heard at the apex
VSD a the left sternal border and has a thrill
Ghent Score consistent with Marfans
>= 7