09/10 - Salivary Gland Disease Flashcards

1
Q

What is a common cause of oral mucosal swelling in children and young adults?

A

mucocele/ranula

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2
Q

Where is a mucocele/ranula most often located?

A
  • lower lip (75%)
  • buccal mucosa
  • ventral tongue
  • floor of the mouth
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3
Q

Describe a mucocele/ranula.

A

non-tender, soft swelling, translucent to blue to normal color depending on the depth of mucus spillage

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4
Q

What is the difference between a mucocele or ranula?

A

a ranula can be found on the floor of the mouth

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5
Q

What does a mucocele/ranula look like histologically?

A

extravasated mucin, granulation tissue, and variable numbers of inflammatory cells

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6
Q

What is the recommended treatment for a mucocele/ranula?

A
  • excision of the mucous deposit together with involved gland
  • unroofing procedure with ranula
  • may recur (warn the patient)
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7
Q

True or false: A mucocele will resolve on its own.

A

FALSE

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8
Q

Why may a mucocele recur?

A
  • because widened salivary gland duct

- because damage to adjacent salivary gland during excision

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9
Q

What glands are most often affected by sialolithiasis?

A

submandibular gland most often but may be parotid and minor glands as well

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10
Q

True or false: Sialolithiasis is always symptomatic.

A

FALSE. It may or may not be symptomatic

*if it is, patient will complain of swelling of involved gland prior to or during meals

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11
Q

What are the clinical and radiographic findings of sialolithiasis?

A
  • hard submucosal mass in soft tissue

- soft tissue film will show an opaque, lamellated structure

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12
Q

What is the recommended treatment for sialolithiasis?

A
  • surgical excision (ligate before incision otherwise stone may retreat)
  • if submandibular gland is involved, evaluate function to determine if gland should be removed
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13
Q

What is acute sialadentitis?

A

bacterial, often penicillinase-producing staph move into the gland and infect the gland

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14
Q

What is acute sialadentitis associated with?

A

severe xerostomia or may follow general anesthesia (called “surgical mumps”)

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15
Q

What is the clinical presentation of acute sialadentitis?

A
  • diffuse, painful and tender, unilateral swelling
  • usually a parotid gland
  • purulent exudate expressed from the parotid papilla
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16
Q

What is the recommended treatment for acute sialadentitis?

A
  • culture and test sensitivity of bacteria
  • penicillinase-resistant penicillin initially
  • adjust antibiotic depending on culture and sensitivity results
17
Q

What is chronic sialadentitis associated with?

A
  • may follow acute sialadentitis due to ductal damage

- often associated with sialolithiasis

18
Q

What gland is usually affected by chronic sialadentitis?

A

submandibular gland

19
Q

What does the sialography imaging look like for chronic sialadentitis?

A

“sausage-link” appearance of ductal system

20
Q

Describe the appearance of chronic sialadentitis histologically.

A

the acini are gone and replaced by scar tissue (called chronic sclerosing sialadentitis; has been under inflammation and infection over time)

21
Q

What is the recommended treatment for chronic sialadentitis?

A
  • antibiotic therapy, such as tetracycline
  • massage and sialogogues (ex. lemon drops, which get patients to express saliva through)
  • ductal ligation or removal of offending gland if problem fails to resolve
22
Q

What is xerostomia? What is it usually associated with?

A
  • subjective symptom of dryness

- associated with glandular hypofunction

23
Q

What is the most common cause of xerostomia in the USA?

A

medication-related xerostomia

24
Q

What medications cause xerostomia?

A
  • antihistamines
  • antidepressants
  • sedatives and anxiolytic agents
  • antihypertensive agents
25
What are other causes of xerostomia, other than medications?
- radiation therapy with salivary glands in the field - Sjorgren syndrome - graft vs. host defense
26
What does xerostomia result in?
- mucosa that is susceptible to injury - candidiasis - increased dental caries
27
What is the recommended treatment for xerostomia?
- artificial saliva/lubricants - sialogogues (sugar free lemon drops, Salagen (pilocarpine), or Evoxac (cevimelie) - 1% neutral sodium fluoride gel or toothpaste nightly - antifungal therapy, as needed
28
Describe a benign lymphoepithelial lesion (BLEL).
unilateral or bilateral firm non-tender swelling of the parotid area
29
What other disease is BLEL associated with?
- BLEL may represent an isolated form of Sjogren's syndrome | - a portion of the infiltrate is monoclonal, maybe a low-grade lymphoma in-situ
30
Who is most at risk for BLEL?
females middle-aged or older
31
How is BLEL visualized via sialography?
"blossoms on a tree" pattern of punctate sialectasis
32
What is the etiology of BLEL?
destruction of the normal parotid parenchyma with replacement by a diffuse lymphocytic infiltrate
33
What is the histopathology of BLEL?
epimyothelial islands (which probably represent residual ductal structures; can also be seen in lymphoma)
34
What is the recommended treatment for BLEL?
varies from doing nothing to low-dose radiation or corticosteroid therapy (steroids especially for IgG4 patients)
35
What is the prognosis of BLEL?
good but malignant transformation of both the lymphoid component or the epithelial component has been reported