07_Antibiotic Essential Comparisons_Jonathan and Yinka Flashcards
Of the Antimetabolites what microorganisms are halted or killed by…
Sulfanilamide?
Trimethoprim?
Isoniazid?
Sulfanilamide»_space; wide range of bacteria and protozoa
Trimethoprim»_space; wide range of bacteria and protozoa
Isoniazid»_space; M. tuberculosis (mycobacteria)
Note: Sulfanilamide and Trimethoprim are static.
Isoniazid is cidal
Of the penicillins, what microorganisms are killed by... Penicillin G and Penicillin V Ampicillin and Amoxicillin Tricarcillin Piperacillin Methicillin and Oxacillin
Penicillin G and Penicillin V»_space; G+ and some G- cocci (meningitis and ypphilis) (note V is acid stable)
Ampicillin and Amoxicillin»_space; G- enteric and most G+ (note ampicilin is acid stable)
Tricarcillin»_space; G- bacilli, P. Aeruginosa, some G-
Piperacillin»_space; G- bacilli, P. Aeruginosa, anaerobes, and some G +
Methicillin and Oxacillin»_space; some G+ (note Oxacillin is acid stable)
Of the Cephalosporins, what microorganisms are killed by... Cefazolin? Cefuroxime? Ceftriaxone? Ceftazidime?
Cefazolin»_space; G+ and some G- enteric
Cefuroxime»_space; more G- and less G+
Ceftriaxone »_space; broad G- and high penetration to blood brain barrier
Ceftazidime»_space; broad G- and P. Aeruginosa
Of the B-lactams, what microorganisms are killed by…
Aztreonam?
Imipenem?
Aztreonam»_space; aerobic G- and P. aeruginosa
Imipenem»_space; broadest antimicrobial spectrum
Of the Glycopeptides, what microorganisms are killed by…
Vancomycin?
Cycloserine?
Bacitracin?
Vancomycin»_space; G+ multiply resistent enterococcus and MRSA
Cycloserine»_space; M. Tuberculosis (toxic, so 2ndary choice only)
Bacitracin»_space; G+ (toxic, topical)
What microorganisms are killed by Polymyxin B?
G- enteric and Pseudomonas
Of the Aminogycosides, what microorganisms are killed by…
Streptomycin?
Gentamycin?
Streptomycin»_space; M. Tuberculosis
Gentamycin»_space; doesn’t say
Of the Tetracyclines, what microoganisms are halted by…
Doxycycline?
Tigecycline?
Doxycycline and Tigecycline»_space; are affective against a broad spectrum of microorganisms including mycoplasma, rickettsia, chlamydia.
Note: Tigecycline is the most potent tetracycline. It means business.
Of the 50s inhibitors, what microorganisms are halted by... Erythromycin? Azithromycin? Chloramphenicol? Clindamycin? Sreptogramins?
Erythromycin»_space; G+ similar to penicillin, mycoplasma, and chlamydia.
Azithromycin»_space; broader spectrum than erythromycin (has long half life and high concentration at site of infection due to penetration of macrophages)
Chloramphenicol»_space; some anaerobes, B. fragilis
Clindamycin»_space; G+ moderate anaerobes
Sreptogramins»_space; MRSA and VREF
What microorganism is halted by the Oxazolidinone: Linezolid aka Zyyox?
G+
VREF
MRSA
What microorganism is halted (low concentration) or killed (high concentration) by Mupirocin?
MRSA, especially nasal MRSA
Of the DNA Replication Inhibitors, what microorganisms are killed by…
Ciprofloxacin and Moxifloxacin (Quinolones)?
Metronidazole (Nitroimidazole)?
Ciprofloxacin and Moxifloxacin (Quinolones)»_space; G- enteric baccili, some G+, and P. aeruginosa
Metronidazole (Nitroimidazole)»_space; Anaerobic (Bacteroides) and Protozoa (trichomoniasis and amebiasis)
Of the RNA synthesis inhibitors, what microorganism is killed by Rifampin?
Broad spectrum
Other antibiotics not otherwise classified that halt or kill Tuberculosis are?
Ethambutol (static)
Pyrazinamide (cidal)
Of the antifungals whic are cidal and which are static... Amphotericin B (polyene) Nystatin (polyene) Fluconazole & Ketoconazole (azole) Caspofungin (echinocadin) Flucytosine
Amphotericin B (polyene) >> cidal Nystatin (polyene) >> usually static, cidal at high doses Fluconazole & Ketoconazole (azole) >> static Caspofungin (echinocadin) >> cidal Flucytosine >> static and cidal