07 Ultrahypofractionation in PCa

Question 1

Ultrahypofractionation trials in PCa

Answer 1

HYPO-RT PC
PACE-B
NRG GU005 Phase II (ongoing) comparing 36.25/7.25 versus 70/2.5 Gy
Miami HEAT (ongoing) comparing 36.25/7.25 versus 70/2.7 Gy
Proton Phase III (ongoing) comparing 38/7.6 versus 79.2/1.8 Gy

Question 2

Ultrahypofractionation trials in PCa: HYPO-RT PC

Answer 2

Question 3

Ultrahypofractionation trials in PCa: PACE-B

Answer 3

Question 4

Contraindications to SBRT (Tree ESTRO 2023)

Answer 4

Lower urinary tracts symptoms (e.g flow-rate < 10 ml/s or Post-void residual > 150 ml)
Risk groups where oncological efficacy not proven (Gleason 8+, PSA 20+, T3/4)