0604 - Effector (and memory) T cells - CS

Question 1

When CD4+ cells differentiate into Th1 cells, name: 1) the cytokine signal recognised; 2) the transcription factor; 3) the master transcriptional regulator and 4) the signature cytokine released

Answer 1

1) IL 12 signal recognised
2) STAT 4 transcriptional factor
3) T-Bet master transcriptional regulator
4) Interferon-gamma released (also IL 2)

Question 2

When CD4+ cells differentiate into Th2 cells, name: 1) the cytokine signal recognised; 2) the transcription factor; 3) the master transcriptional regulator and 4) the signature cytokine released

Answer 2

1) IL-4 and IL-2 signal recognised
2) STAT 6 transcriptional factor
3) GATA 3 master transcriptional regulator
4) IL-4 released (also IL 2)

Question 3

When CD4+ cells differentiate into Th17 cells, name: 1) the cytokine signal recognised; 2) the transcription factor; 3) the master transcriptional regulator and 4) te signature cytokine released

Answer 3

1) IL-6, IL-1b, TGF-beta signals recognised
2) STAT 3 transcriptional factor
3) ROR-gamma t master transcriptional regulator
4) IL-17 (also IL 2) released

Question 4

When CD4+ cells differentiate into T follicular helper (Tfh) cells , name: 1) the cytokine signal recognised; 2) the transcription factor; 3) the master transcriptional regulator and 4) te signature cytokine released

Answer 4

1) IL 21 signal recognised
2) ?
3) Bc16 master transcriptional regulator
4) IL-21, IL-4, IL-10 released

Question 5

When CD4+ cells differentiate into T regulator cells, name: 1) the cytokine signal recognised; 2) the transcription factor; 3) the master transcriptional regulator and 4) the signature cytokine released

Answer 5

1) IL-2 and TGF-beta signals recognised
2) STAT 5 transcriptional factor
3) FoxP3 master transcriptional regulator
4) TGF-beta released

Question 6

What sort of response is stimulated by Th1 cells

Answer 6

Recruit and activate macrophages, Dendritic cells, Intracellular pathogens

Question 7

What sort of response is stimulated by Th2 cells

Answer 7

B cell proliferation

Class switch recombination to IgE

Eosinophil recruitment and actvation

Mucsal secretion

Gut peristalsis

Question 8

What sort of response is stimulated by Th17 cells

Answer 8

Rcruitment and activation of neutrophils

Stimulate epithelial cells (eg keratinocytes), extra cellular bacteria and fungi

Question 9

What is the role of T follicular helper cells?

Answer 9

Involved in germinal centre reactions in B activation

Question 10

What is the role of T regulator cells?

Answer 10

Dampens immune response by slowing rate of proinflammatory cytokines