02 Treatment of GERD Flashcards
What is GERD, and what are its primary symptoms?
GERD (gastroesophageal reflux disease) occurs when stomach acid flows back into the esophagus, causing symptoms like heartburn.
What are the treatment approaches for mild, uncomplicated GERD?
Antacids are used for occasional dyspepsia in mild, uncomplicated GERD.
What is the preferred treatment for moderate to severe GERD?
Proton pump inhibitors (PPIs) are the preferred treatment for moderate to severe GERD.
When are prokinetic agents used in GERD treatment?
Prokinetic agents are used as adjunctive therapy if additional symptom relief is needed.
How do antacids work, and what is their limitation?
Antacids neutralize stomach acid for rapid relief but do not decrease acid production.
When should antacids be taken for optimal effect?
Antacids should be taken one hour after meals for a longer duration of action. Their effects are shorter-lived when taken on an empty stomach.
Why should antacids be taken two hours apart from other medications?
Antacids have common drug interactions and can interfere with the absorption of other medications.
What is the mechanism of action of H2 receptor blockers?
H2 blockers reduce gastric secretion volume and acidity by competitively inhibiting histamine at H2 receptors on parietal cells.
How do H2 blockers compare to PPIs in treating GERD?
H2 blockers are less effective than PPIs for moderate to severe GERD.
How do PPIs work to treat GERD?
PPIs irreversibly inhibit the H+/K+ ATPase pump (proton pump) on parietal cells, blocking the final step of acid secretion.
What are the benefits of PPIs in GERD treatment?
PPIs provide rapid symptom relief and promote healing of esophageal lesions.
When should PPIs be taken for the best results?
PPIs should be taken one hour before meals for optimal effectiveness.
Why might GERD treatment require a long-term approach?
GERD symptoms often return when medication is stopped, necessitating ongoing management.
What are important non-pharmacological measures for GERD management?
Avoiding large meals, late-night eating, smoking, and alcohol are key non-pharmacological measures for GERD.
What bacterium is associated with gastritis, peptic ulcers, and stomach cancer?
Helicobacter pylori (H. pylori).
What does the treatment of H. pylori infections typically involve?
Combination regimens of 2-4 drugs for 1-2 weeks are used to eradicate H. pylori.
What is a common three-drug regimen for treating H. pylori?
Clarithromycin + metronidazole + omeprazole.
What is another example of a drug combination for H. pylori treatment?
Amoxicillin + tinidazole + lansoprazole.
How do PPIs enhance the effectiveness of antibiotics in treating H. pylori?
PPIs reduce gastric acid, creating a more favorable environment for antibiotics to work against H. pylori.
What factors must be considered when selecting antimicrobials for H. pylori treatment?
Mechanism of Action: Ensure drugs target H. pylori effectively (e.g., disrupting bacterial DNA, inhibiting protein synthesis, or damaging bacterial membranes).
Adverse Effects: Consider patient tolerability, such as avoiding metronidazole in those prone to disulfiram-like reactions or tetracycline in pregnant patients.
Drug Interactions: Be cautious with drugs that interact with PPIs (e.g., clopidogrel) or antibiotics (e.g., metronidazole with alcohol).
Antibiotic Resistance: Tailor therapy based on regional resistance patterns, especially for clarithromycin and metronidazole.
Clinical Effectiveness: Choose regimens proven to achieve high eradication rates (e.g., quadruple therapy in areas of high resistance).
Why might PPIs be preferred over antacids and H2 blockers for moderate to severe GERD?
PPIs provide long-lasting acid suppression, promote healing of esophageal lesions, and effectively manage chronic symptoms, unlike antacids (rapid but short-term relief) or H2 blockers (less effective for severe cases).
What non-pharmacological strategies could complement medication in GERD management?
Elevating the head of the bed during sleep.
Weight loss in overweight patients.
Avoiding trigger foods such as caffeine, chocolate, and fatty meals.
What is a potential drawback of long-term PPI use?
Long-term PPI use may be associated with risks like vitamin B12 deficiency, hypomagnesemia, and an increased risk of bone fractures or infections like Clostridioides difficile.
How can H. pylori infection lead to more severe complications if untreated?
Persistent H. pylori infection can cause chronic gastritis, peptic ulcers, and is a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma.
Why is it important to use combination therapy for H. pylori infections?
Combination therapy reduces the risk of bacterial resistance and ensures higher eradication rates by targeting H. pylori through multiple mechanisms.
When using a regimen involving clarithromycin for H. pylori, what should be considered to reduce treatment failure?
Regional clarithromycin resistance rates should be assessed. High resistance rates may necessitate alternative antibiotics or quadruple therapy.
Why is it critical to complete the full course of H. pylori eradication therapy?
Incomplete treatment increases the risk of bacterial resistance and recurrence of infection.
What is the primary role of PPIs in H. pylori eradication regimens?
PPIs suppress gastric acid production, enhancing antibiotic stability and effectiveness, and creating an unfavorable environment for H. pylori growth.
How does the mechanism of action differ between antacids and PPIs in managing GERD symptoms?
Antacids neutralize existing stomach acid for immediate relief, whereas PPIs inhibit acid secretion at the proton pump level for long-term relief.
How can drug interactions complicate GERD or H. pylori treatments?
Antacids can impair absorption of medications like tetracyclines or fluoroquinolones.
PPIs may interact with drugs like clopidogrel, potentially reducing its effectiveness.
Metronidazole (used in H. pylori treatment) can cause a disulfiram-like reaction with alcohol.
