02: (2018 Debnah & Greenblatt) + (2019 Pineault & Wellik) Flashcards
1
Q
What is the name of the 2018 Debnah & Greenblatt paper?
A
“Discovery of a periosteal stem cell mediating intramembranous bone formation”
2
Q
What is the name of the 2019 Pineault & Wellik paper?
A
“Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life”
3
Q
What is the singular main point from (2019 Pineault & Wellik)?
(3 points)
A
- Their studies show that Hox expressing cells are skeletal stem cells that arise from the earliest stages of skeletal development and self-renew throughout the life of the animal.
- They generated Hoxa11- CreERT2 lineage-tracing system to show Hoxa11-lineage marked cells give rise to all skeletal lineages throughout the life of the animal and persist as MSCs.
- Hoxa11 lineage-positive cells give rise to previously described progenitor-enriched MSC populations marked by LepR-Cre and Osx-CreER, placing them upstream of these populations.
4
Q
What is the general role of Hox genes?
A
Hox genes play well-established roles in patterning the embryonic skeleton.
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