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Tufts Pharm - NBDE II > 01 - Local Anesthetics > Flashcards

01 - Local Anesthetics Flashcards

1
Q

List the Esters

A

Procaine
Tetracaine
Cocaine

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2
Q

Esters are metabolized by ______

A

Plasma Esterases

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3
Q

Procaine

Amide or Ester

A

Ester

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4
Q

Tetracaine

Amide or Ester

A

Ester

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5
Q

Cocaine

Amide or Ester

A

Ester

Bonus: Only Vasoconstrictor

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8
Q

Lidocaine

Amide or Ester

A

Amide

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9
Q

Mepivicaine

Amide or Ester

A

Amide

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10
Q

Bupivicaine

Amide or Ester

A

Amide

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11
Q

Prilocaine

Amide or Ester

A

Amide

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12
Q

Dibucaine

Amide or Ester

A

Amide

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14
Q

List the Amides

A 
Lidocaine
Mepivicaine
Bupivicaine
Prilocaine
Dibucaine
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15
Q

Amides are metabolized in the ________

A

Liver

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21
Q

High Systemic Levels of LA lead to _______ via _____ & _____

A

Cardiovascular Collapse
via
Myocardial Depression
Hypotensive Shock

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22
Q

Toxic Reaction of Prilocaine

A

Methemoglobinemia
aka
Tissue Hypoxia

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23
Q

Mechanism of LA

A

Interfere w/Na+ transport into the neuron

Preventing nerve impulses

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24
Q

Only the ______ form of LA can penetrate tissue membranes

A

Free-Base/Nonionized/Basic

25
Q

Initial Rxn to High Levels of LA

A

CNS Stimulation
by
Reduction of Inhibitory Neurons

26
Q

Eventual Rxn to High Levels of LA

A

CNS Depression/Death
by
Reducing both Inhibitory & Excitatory neurons

Tufts Pharm - NBDE II (2 decks)

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