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Jess Law
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Decks in this class (15)
Neurons and Astrocytes
Describe how neurons are adapted to their function according to their location in the CNS
Appreciate the diversity of neuronal subtypes through their cellular structure
Describe the varied function of astrocytes
Discuss the cell-cell interactions of astrocytes with other CNS cells
Relate the biology of neurons and astrocytes to nervous system physiology and pathology
36
cards
Microglia
Describe the origin of microglia and other CNS myeloid cells
Understand the roles of microglia in health
Understand the contribution of microglia to disease
31
cards
Oligodendrocytes and Schwann Cells
Describe the steps in the development of the oligodendrocyte from early precursor to myelinating cell
Discuss how the number of oligodendrocytes becomes matched to the number of axons requiring myelination
Contrast oligodendrocyte development and function with Schwann cell development and function
49
cards
Axon Growth
Understand the basic mechanisms of axon growth and guidance during development
Understand the main classes of molecules and pathways guiding axon growth during development
36
cards
Axon Regeneration
Understand the reasons for regenerative failure after CNS injury
Know the main molecules and pathways behind regenerative failure
Know examples of interventions with regenerative success
32
cards
Axon Growth And Regeneration
Name a local and distal effect of...,
Name the 3 types of extracellular...,
State 4 ways in which the growth ...
49
cards
CNS Tumours
Know the major types of CNS tumours
Know how to grade CNS tumours
Know the major risk factors and genetic predisposition for CNS tumours
Know the existing treatments and treatment resistance
Understand the major imaging modalities
41
cards
Therapeutic Targeting of CNS Tumours
Understand brain tumour resistance to current treatments
Appreciate the challenge of the blood-brain barrier
Know strategies used in clinic to overcome the blood-brain barrier
Appreciate new drug delivery systems for brain tumour treatment
Appreciate how drug delivery systems can make treatment safer and more selective
Evaluate the use of anti-angiogenic agents against glioblastoma
39
cards
Neurodevelopment
Name 2 methods of studying circui...,
Describe confocal microscopy,
Give an advantage of 2 photon mic...
17
cards
Neurodevelopmental Disease
Understand the principle modes of inheritance
Understand how germline and somatic mutations can contribute to neurodevelopmental disease
Understand how neurodevelopmental disease can originate from genetic defects in neuronal proliferation, neuronal migration, and neuronal connectivity
Understand how precision medicine can be applied to neurodevelopmental disease
21
cards
Stem Cells and Neurogenesis
Define the properties of stem cells
Describe the similarities and differences between pluripotent and tissue-specific stem cells
Discuss the importance of pluripotent cells in neuroscience
Define the properties and localisation of neural stem cells in the CNS
Discuss how neural stem cells are temporally and spatially regulated during development
23
cards
Neural Stem Cells
Define the properties of stem cells
Describe similarities and differences between pluripotent and tissue-specific stem cells
Define the properties and localisation of neural stem cells in the CNS
Discuss that neural stem cells are temporally and spatially regulated during development
24
cards
Tissue Culture and Immunocytochemistry
Discuss the conditions required for cells and tissues to thrive outside of the body
Describe the fundamental techniques enabling cell culture, including equipment and reagents used
Critically evaluate the methods used to separate different types of mammalian cells
Discuss ways of measuring cell survival, proliferation, and apoptosis
15
cards
Pain
Describe the anatomy of the sensory nervous system
Understand the gate control theory of pain
Identify the key molecules involved in pain pathways
Understand how voltage-gated sodium channels are involved in pain pathways
50
cards
Pain 2
Which four voltage gated sodium c...,
Which two voltage gated sodium ch...,
Which sodium channel is found in ...
23
cards
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Neuroscience 1
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