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Jenna Tapper
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Decks in this class (20)
E1 L1: IV Bolus
Pk definition 1,
Adme 2,
Two major elimination pathways 3
33
cards
E1 L2: Drug Distribution
Passive diffusion properties 1,
Transcellular junctions 2,
Paracellular diffusion 3
38
cards
E1 L3: Constant Rate Regimen
Q tf the time to reach steady sta...,
T f if you increase the dose tss ...,
T f doubling the dose will double...
4
cards
E1 L4: Oral Dosing
3 routes of admin 1,
Peak concentration at cp0 2,
Drug accumulates in the body unti...
33
cards
E1 L5: Hepatic Drug Metabolism
Oxygen rich blood flows into the ...,
Blood flows out of the liver thro...,
Nutrient rich blood coming from t...
42
cards
E1 L6: Bioavailability and Clearance 1
Fraction of the administered dose...,
The value of f is termed 2,
Bioavailability units and range 3
34
cards
E1 L7: Bioavailability and Clearance 2
What determines eh 1,
Eh 2,
Max organ clearance values are eq...
38
cards
E1 L8: Bioavailability and Clearance 3
Fa 1,
Eg 2,
Bioavailability f equation 3
13
cards
E1 L9: Bioavailability and Clearance 4:
When fe is 0 1,
What directional changes in auciv...,
What directional changes in aucpo...
46
cards
Ex 2. L1: Multiple Dosing Regimen
Infusion vs multiple dosing 1,
Do you reach steady state at the ...,
Principles of drug accumulation i...
17
cards
Ex 2. L2: Multi Dose II
Dosing regimen steps 1,
1 know the target concentration r...,
2 determine the max dosing interv...
7
cards
Ex. 2 L3: Multicompartmental analysis
Multicompartment 1,
2 compartment pk model aka 2,
One compartment model 3
23
cards
Ex. 2 L4: Noncompartmental Analysis
Noncompartmental analysis 1,
Noncompartmental variables 2,
Clearance and compartmental analy...
22
cards
Ex 2. L5: Metabolite Kinetics
Overview of metabolite pk 1,
Importance of metabolite pk 2,
Contribution of metabolites to dr...
42
cards
Ex. 2 L6: Drug Transporters
Types of drug transport 1,
Uptake and efflux transport use 2,
Role of drug transporters in drug...
39
cards
Ex. 2 L7: PK of Biological drugs
What are biologics 1,
Biologics examples 2,
Mabs 3
42
cards
Ex. 2 L8: Nonlinear PK
Nonlinear intro 1,
Absorption mechanisms 2,
Example drugs saturable transport...
24
cards
Ex. 2 Practice Questions
L1 t f higher dose is expected to...,
L1 when you switch dosage regimen...,
L1 when you switch dosage regimen...
35
cards
Final L1 - PKD 1
Pharmacodynamics definition 1,
Pharmacodynamics 2,
Importance of pk pd 3
30
cards
Final L2 - PK in Renal disease
Ideal marker of gfr 1,
Assessment of kidney function 2,
Cg 3
11
cards
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Kinetics
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