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Decks in this class (11)
Genomic Programming
Define euchromatin dna,
Define heterochromatin dna,
What is the role of epigenetic re...
68
cards
Eukaryotic Transcription and Gene Regulation
Role of rna polymerase i,
Role of rna polymerase ii,
Role of rna polymerase iii
36
cards
DNA repair
Understand that...
- the development of cancer requires the acquisition of new properties by cells which require genetic change in these cells
- tumor cell evolution is driven by natural (clonal) selection causing non-linear diversification. The resulting tumor cells may become genetically vastly different from how they started
36
cards
Nrf2
- What is Nrf2, how is it regulated, and why does it promote cell survival
- What are cyanoenone triterpenoids
- How do cyanoenone triterpenoids activate Nrf2
- What is the evidence that Nrf2 protects against inflammation
- What is itaconate and how does it activate Nrf2
- That Nrf2 is inactivated in certain viral infections
- The effect of pharmacological Nrf2 acrtivators in viral infections
30
cards
Spatial control of cell division
Cell division is needed for,
G1 phase checkpoint,
G2 phase checkpoint
31
cards
Sulforaphane
- What is sulforaphane
- How does sulforaphane activate Nrf2
- Why is sulforaphane effective in so many animal models of human disease
- What type of human disease sulforaphane is most likely to affect
- The importance of the dose for optimal efficacy
- The feasibility and challenges associated with translation of findings in animal models to humans
30
cards
Formation and degeneration of pancreatic beta cells
Importance of endocrine pancreas,
Islet endocrine cell types,
Maintenance of normoglycaemia 5 7...
24
cards
Cancer, stem cells, and cancer stem cells
- Define tissue stem cells
- Explain what is meant by the term "cancer stem cell"
- Contrast the terms "tissue stem cell" and "cancer stem cell"
- Theorise about the relationship of tissue stem cells to cancer cells of origin
25
cards
Cell signalling
- Oncogenes and tumour suppressors talk to each other
- Complexity and mechanisms of cell signalling
- The main components of cell signalling
- Types of ligands and receptors
- Major post-translational modifications and the contribution of Dundee scientists
- How RTKs play a role in cancer
- Targeting kinases in cancer: Malignant melanoma
- Ubiquitin proteasome system
23
cards
Post-translational-modifications
- The relevance of PTMs as a way to increase protein complexity
- The use of PTMs as a quick response to stimuli
- Different types of PTMs and their regulation. Writers, erasers, readers
- Mechanisms of protein regulation via PTMs
- PTMs crosstalk
23
cards
Apoptosis
Apoptosis,
Necrosis,
Characteristics of apoptosis
42
cards
More about
Cell Proliferation and Survival Mechanisms Underlying Disease
- Class purpose General learning
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