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amie briggs
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Decks in this class (25)
25th Jan - Trx 1
Outline the central dogma,
Who proposed the concept of an in...,
Which rna is encoded by pol i
18
cards
26th Jan - Transcription II
What is ensembl,
How do you create a cdna library,
What are the benefits of cdna ove...
11
cards
27th Jan - Defining the Transcriptome
How many protein coding rnas are ...,
What are retained introns,
What are the two main forms of ac...
25
cards
30th Jan - Epigenetic Regulation
What is epigenetics,
What is the function of dna methy...,
Which base is methylated in eukar...
33
cards
1st Feb - Chromatin Movers and Modifiers
What are nucleosome remodelling c...,
What are the key families of nucl...,
What percentage of cancers is swi...
31
cards
2nd Feb - Transcription VI
What are the four key stages of p...,
Who won the nobel prize in chemis...,
Why is rnap ii nicknamed a poor e...
22
cards
13th Feb - TFs = key determinants of cell fate
What are master transcription fac...,
Give an example of a master tf,
What is the key limitation in ind...
21
cards
15th Feb - Interpreting the signal
Outline er activation,
Give an example of an er target gene,
How can er activity be shown
23
cards
17th Feb - Discovery of Splicing and the Essential Sequences
Who elucidated that genes must en...,
What is the information problem,
When did crick propose his centra...
14
cards
20th Feb - Splicing, In Vitro and the chemical reactions
What are the two major problems f...,
What was the solution to producin...,
What was the solution to getting ...
10
cards
22nd Feb - RNABP
How was the stepwise assembly of ...,
Outline the experiment that used ...,
Outline the experiment that used ...
25
cards
Fundamentals of Splicing - Stryer
Why must splicing location be ext...,
What is the consensus sequence at...,
What is the consensus sequence at...
6
cards
23rd Feb - Components that recognise essential sequences at splice sites
Describe the u1 snrnp,
How was it tested that the u1 snr...,
How does u1 interact with the 5ss
10
cards
24th Feb - The First Steps of splicing
What is uap56,
What are the components of complex e,
What helps u2f65 and u2f35 bind
16
cards
27th Feb - B--> Bact --> C--> C* and Post-splicing
How is complex e accumulated for ...,
How is complex a accumulated for ...,
How is complex b accumulated for ...
15
cards
3rd March - Is the Spliceosome a ribozyme? What is its origin? What is the process in vivo?
What is special about group ii in...,
Describe the structure of group i...,
Why do the group ii introns activ...
9
cards
6th March - All Splicing involves selection among alternative possibilities
What percentage of protein coding...,
What percentage of intron contain...,
Approximately how many isoforms o...
11
cards
6th March - What effects splicing patterns?
In a simple gene which has two al...,
What is the common function of sr...,
What do sr proteins bind to in dna
20
cards
8th March - The impact of transcription on splicing efficiency and splice site selection
Outline an experiment that measur...,
Outline an experiment that measur...,
Why is splicing in vivo faster th...
8
cards
9th March - Splicing in Cancer
What mutation in splicing causes ...,
What are the causes of myelodyspl...,
What is myelodysplasia
11
cards
10th March - Therapies, mRNA export
What is morpholino,
How can pro apoptotic isoforms of...,
What is the problem with using ol...
13
cards
6th Feb - TFs 1
What are transcription factors,
How were enhancers originally ide...,
What are enhancers
19
cards
8th Feb - Nuclear Receptors
When were steroids first utilised...,
When were steroid receptors ident...,
Why are nuclear receptors easy to...
27
cards
9th Feb - Co-regulator recruitment to TFs
Which region of the nr is very se...,
How is the thermostability of the...,
What do mutated v290 p467 and a23...
19
cards
10th Feb - How structures have helped us understand gene regulation in a chromatin environment
What do phd domains bind to,
What do chromodomains bind to,
What do bromodomains bind to
11
cards
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BS3010
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