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Decks in this class (12)
Membranes and Lipid Proteins
- Recognise the basic types of membrane lipid and the amphipathic nature of phospholipids
- Describe membrane structure in terms of the classical "fluid-mosaic" model and list evidence supporting the model
- Predict the effect of variations in chemical composition (e.g. of phospholipids) on membrane properties
- Differentiate between single-spanning and multiple spanning membrane proteins in terms of likely cellular function
37
cards
Diffusion and Osmosis
- Explain diffusion across a membrane in terms of a generalised Force-Flow relationship
- Relate the diffusion coefficient to permeability (considering Fick's Kaw applied to membranes)
- Interpret likely effects of size, shape and charge of molecules on their permeation through a membrane
- Appreciate the concept of water potential in relation to oasmotic water movement
17
cards
Transporters and Channels
- Identify the criteria for the existence of carrier-mediated transfer
- Recognise that gene "families" of transporters have evolved
- Recall Michaelis-Menten equation for the kinetics of simple carrier-mediated transport
- Understand how Km and Vmax provide descriptions of carrier function
- Distinguish between competitive and non-competitive effects on transport of a solute
- Appreciate the consequences of coupling of substrate fluxes through a carrier
31
cards
Structure, Function and Pharmacology of the Na+/K+ ATPase pump
- Describe what is the pump-leak hhypothesis
- Recall evidence that the Na pump is an ATPase
- Describe what energises the pump
- Describe the nature of the cation transport system
- Describe the pump reaction mechanism
- Define the five operational modes of the pump
- Recall the molecular structure of the Na pump, tissue distribution of pump isoforms and pharmacological interactions with the alpha1 subunit
22
cards
Transmitter Release
- Appreciate how electrophysiological, microscopy and biochemical techniques can be used to investigate the release of a neurotransmitter at a synapse
- Describe key experiments used to investigate the role of vesicles in neurotransmitter release
- Understand the role of key synaptic proteins in neurotransmitter release
- Know how to determine the effects of particular drugs and toxins on synaptic transmission
29
cards
ACh Release
Describe how activation of the na...,
How can we study the functional p...,
Describe the patch clamp technique
23
cards
Inhibitory Transmission
What is the gaba a receptor,
What drugs act on gaba a receptor,
What is the gaba b receptor
49
cards
Excitatory neurotransmission
How can ionotropic glutamate rece...,
Primary cation for ampa and kaina...,
What are the three main types of ...
40
cards
NaV Channels
Gating and pore selectivity of th...,
Describe the function of channels...,
How can channels be opened
29
cards
KV Channels
What are potassium channels,
Factors that can regulate potassi...,
What are 6 transmembrane segment ...
37
cards
CaV Channels
- List the subunits that assemble to form a voltage-gated Ca channel
- List the subtypes and corresponding properties of CaV channels
- Explain the importance and mechanism by which phosphorylation and G proteins regulate the Ca current from a CaV channel
- Describe the clinical importance of Ca channels and list the channelopathies that may result from inherited mutations in CaV genes
37
cards
Transporters and Channels 2
Transporters in facilitated diffu...,
Transporters in active transport,
What are p glycoprotein transporters
20
cards
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Biomembranes
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