Pharm Exam 1 Flashcards
Teratogen
Causing abnormal fetal development
Pharmacokinetics
Study of how the drugs moves through the body; drug transit after it has been administered.
- Absorption - GI
- Distribution - Cardiovascular
- Metabolism (biotransformation) - Liver
- Excretion -Urinary System mostly
- Half Life
Pharmacodynamics
Action of the drug and effect within the body.
Absorption
Movement of drug from site of administration to body fluids.
- Oral Meds (Gastrointestinal and integumentary system)
- Topical & Sub-Q (Skin)
- IM (Muscles)
- IV (Skips this step)
Distribution
Deliver of drug from circulatory system to target tissue or site.
*Cardiovascular system
Metabolism (Biotransformation)
Deactivation of drug for excretion.
*Liver
Excretion
Elimination of drugs from the body.
*urinary system mostly
Half-life
Time required for the body to eliminate half of the drug.
Onset
Time between drug administration and when it starts to exert its effects.
Peak
The point at which absorption and excretion are equal.
Duration
Length of time drug produces its effect.
Primary Effect
The desired or therapeutic effect of a drug.
Secondary Effect
Any effects of a drug other than the therapeutic effect.
Drug-drug Interaction
The impact that 1 drug may have on the effect of another.
Additive Drug Reaction
Administration of 2 meds together to achieve a combined effect.
(1+1=2)
Antagonist Drug Reaction
1 drug interfering with decreasing, or blocking the action of another.
(1-1=0)
Adverse Reaction
Undesirable drug effects
Allergic Reaction
Immune system activation triggered by exposure to a medication.
Drug Idiosyncrasy
Unusual or atypical response to a drug.
Drug tolerance
Decreasing response to a drug that requires an increase in dosing.
Toxic Reactions
Harmful effects of a drug that may impact organ function.
Cumulative Effect
Accumulation of drugs due to impaired organ function.
Drug-food Interaction
Changes in drug absorption resulting from ingestion of food.