absite part 2 bored Flashcards
clinical significance of criminal nerve of grassi
can cause persistently high acid levels if left undivided after vagotomy
Normal UES resting pressure vs normal LES resting pressing
UES: 60
LES: 15
Cancer associated with plummer vinson syndrome?
Oral cancer
pathophysiology of zenker’s diverticulum?
increase in pressure due to failure of cricopharyngeus muscle to relax
gold standard for diagnosis of zenker’s diverticulum?
Barium swallow
Traction diverticulum of the esophagus
True diverticulum
most commonly located in the mid lateral esophagus
epiphrenic diverticulum
A false diverticulum most commonly located in the distal 10cm of the esophagus
Mainly associated with motility disorders
pathophysiology of achalasia
destruction of inhibitory neural ganglion cells in muscle wall
manometric findings of achalasia
*high/normal pressure LES
*poor/no peristalsis
pathophysiology of scleroderma
fibrous displacement of esophageal smooth muscles
histopathology seen in barrets esophagus
goblet cells
Ca risk is increased by how much in barrets esophagus
50 times adenocarcinoma
Most common esophageal cancer worldwide
squamous Ca
what T stage of esophageal cancer is still resectable
T4a
invasion of pericardium, pleura and diaphragm is considered what T stage
T4a
Most common site of tumor and most common site of distant metastasis for esophageal adeno vs squamous Ca
- Adenocarcinoma – usually in lower ⅓ of esophagus; liver metastases most common
- Squamous cell carcinoma – usually in upper ⅔ of esophagus; lung metastases MC
Fanconi anemia increases the risk for what type of cancer
squamous cell CA of oral cavity and esophagus
what is TYLOSIS
autosomal dominant disease
● Hyperkeratosis of the palms and soles of feet
● 70% lifetime risk of squamous cell esophageal CA
● Upper endoscopy screening starting at age 20
Most common site of non-iatrogenic (mc boerhaave) esophageal perforation
left posterior lateral intrathoracic esophagus 2–4 cm above EGJ
Most common iatrogenic site for esophageal perforation
cervical esophagus near cricopharyngeus muscle
Meissner’s and Auerbach’s
plexuses location in the esophagus
Meissner’s and Auerbach’s
plexuses, are found in the submucosa and between the muscle
layers of the esophagus, respectively.
swallowing center is located in the
Medulla
The most
common operative finding on repeated fundoplication
herniated wrap
source of bleeding in Mallory-Weiss tears
arterial bleeding
most common problem following vagotomy
diarrhea
Best test for H. pylori eradication
urea breath test
gold standard test for h pylori diagnosis
histological examination of antral biopsy
Type 4 gastric ulcers
lesser curve high along cardia of stomach; ↓ mucosal protection
Type 1 gastric ulcers
lesser curve low along body of stomach; due to ↓ mucosal protection
mutation associated with hereditary diffuse gastric Ca
CDH1 mutation (AD)
Types of chronic gastritis
● Type A (fundus)
● Type B (antral)
GIST is considered malignant if
if > 5 cm or > 5 mitoses/50 HPF (high-powered field)
MALT is associated with
H.pylori
dumping syndrome is most common with
billroth 2 surgery
Duodenal diverticula are false or true?
congenital or acquired?
false
acquired
operative treatment of choice for SMA syndrome?
duodenojejunostomy
An aberrant/replaced left hepatic artery originates
from
left gastric artery
Borchardt’s triad
acute epigastric pain, violent retching without vomiting, and the inability
to pass an NG tube
Associated with gastric volvulus
course of replaced left hepatic artery
within the gastrohepatic ligament medially
how to differentiate portal vein from hepatic vein on u/s
portal vein have hyperechoic walls
The ligamentum teres
extends from
the falciform ligament and carries the obliterated umbilical vein to
the undersurface of the liver
Difference between Hepatic adenoma and focal nodular hyperplasia histologically
Hepatic adenoma lacks kupffer cells
screening for HCC
done via u/s only every 6 months for patients at risk
The Milan criteria for HCC
define HCC tumors in Child’s C cirrhosis
that would benefit from transplantation
Characteristics that further support metastasis over primary
liver cancer include
*history of primary cancer
*peripheral residing
lesions
*multiple lesions
* mass hypovascularity (hence only
slightly enhancing compared with adjacent liver parenchyma).
indications for TIPS include
*protracted variceal bleeding
*refractory ascites, *hepatic hydrothorax
*Budd-Chiari syndrome refractory to anticoagulation.
preferred site for needle entry in paracentesis
3 cm medial and 3 cm superior to the ASIS in the left
lower quadrant (LLQ)
Risk factors for Spontaneous bacterial peritonitis
previous SBP
variceal bleeding
low protein ascites
EMPHYSEMATOUS GALLBLADDER DISEASE organism mc involved
Clostridium perferignes
Bacterial infection of bile source
mostly transferred from portal system