1- Fate and Commitment Flashcards
cell fate - define?
the future outcome of a cell/ tissue during development - what it will normally become
commitment - define
process by which a cell’s developmental potential becomes progressively limited - occurs through specification (reversible) and determination (irreversible)
specification - define?
reversible stage of commitment - a cell is directed toward a particular fate but can still be influenced by environmental factors
determination - define?
irreversible stage of commitment - cell’s fate is fixed and it continues its developmental path regardless of external signals
differentiation - define?
process where a cell undergoes molecular changes and limits is potential, leading toa more specialised cell type
potential/ potency - define?
the range of cell types or tissues that a cell can give rise to - larger range means more potential
list the two theories/ mechanisms on cell fate restriction during embryonic development
mosaic development
regulative development
mosaic development - define?
information within a cell is inherited from a parental cell & guides its development autonomously regardless of environment
regulative development - define?
cell’s fate and development are influenced by its surroundings & position – isn’t committed to a certain fate
describe how C. elegans embryos are an example of mosaic and regulative development
how do fate and commitment change through embryonic development (early vs later stages)?
describe how Roux’s experiment on determination is an example of mosaic development - why is this experiment bad proof?
mosaic development is is the process of a cell developing based on inherited determinants from a parental cell - information guides cell’s development autonomously, regardless of environment
Roux’s experiment:
describe how Driesch’s separation of sea urchin blastomeres
