Weeks 16-18 Flashcards

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1
Q

What is the difference between an open loop and a closed loop?

A

Closed takes into account the disturbance of error.

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2
Q

Final effective pathway

A

Brain –> spinal cord –> muscle

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3
Q

Final effector pathway for eye movement

A

Basal ganglia –GABA-> sup. colliculus –Glutamate-> Reticular formation –Glutamate-> Motor neurones –Ach-> Muscles

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4
Q

Final effector pathway for limb movement

A

Basal ganglia –GABA-> Thalamus –Glutamate-> 1st motor cortex –Glutamate-> Motor neurons –Ach-> Muscles

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5
Q

What makes up a motor unit?

A

Motorneurone + innervated muscle fibre

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6
Q

The muscle spindle

A

Spindle is responsible for sensory feedback.

Lies parallel to muscle fibers and detects changes in muscle length.

Enables regulation of muscle contraction and matches force to the task.

Stretch sensitive unit between two contractile units

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7
Q

Stretch of tendons is proportional to

A

Tension exerted by the muscle.

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8
Q

Alpha motorneurones

A

Innervate extrafusal muscle fibres which generate muscle tension.

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9
Q

Gamma motorneurones

A

Innervate intrafusal muscle fibres (spindles). Don’t generate tension.

Makes contracted spindle fiber sensitive to stretch of muscle.

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10
Q

Which sensory afferents have a larger diameter and faster conduction?

A

Groups 1 and 2.

Group 2 are stretch only afferents.

E.g low threshold mechanoreceptors

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11
Q

Which sensory afferents have a smaller diameter and slower conduction?

A

Groups 3 and 4.

E.g nociceptors and thermoreceptors

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12
Q

What innervates the golgi tendon organ?

A

1b afferents.

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13
Q

What is the golgi tendon organ?

A

Mechanoreceptor activated by 1b afferents that detects change in muscle tension.

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14
Q

What does the primary afferent 1a do? What does 1b do?

A

1a senses stretch and rate of change in stretch.

1b signal force change in muscle

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15
Q

What muscle group does monosynaptic pathways innervate?

A

Flexors

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16
Q

What muscle group do poly/oligosynaptic pathways innervate?

A

Extensors

17
Q

The 3 cortical pathways

A

1) Lateral corticospinal tract (skilled limb movements)
2) Ventral corticospinal tract (axial muscle control)
3) Corticobulbar tract (facial muscles)

18
Q

The 4 brain stem motor pathways

A

1) Rubrospinal tract (originates in red nucleus, limb control)
2) Tectospinal tract (originates in sup. colliculus, hand-eye coordination during gaze)
3) Reticulospinal tract (automatic movements and posture)
4) Vestibulospinal tracts (posture and balance)

19
Q

Describe the hierarchical motor organisation

A

Limbic system

Premotor/supplementary motor cortices

Primary motor cortex

Brain stem

Spinal cord

20
Q

Motor cortex (contain upper motor neurons)

A

Located in precentral gyrus (frontal lobe). Broadmans area 4 and 6.

Voluntary movement.

Pyramidal cells in cortical layer V are upper motor neurons.

Axon descends into corticobulbar and corticospinal tracts to spinal cord.

21
Q

Alzheimer’s pathology

A

Cortical atrophy - results in widened sulci and narrowed gyri.

Neuronal loss/shrinkage (cholinergic pathways especially)

Reduced glucose uptake in sufferers (shown in PET scan)

22
Q

Current treatment for alzheimers

A

Acetylcholinesterase inhibitors.

Inc Ach –> slower progression

23
Q

Multiple sclerosis

A

Causes: Degradation of myelinsheath due to failing oligodendrocytes.

Most common in women.

24
Q

Parkinsons disease pathology

A

Diminished substantia nigra (containing dopamine cells)

25
Q

Huntington’s disease

A

Autosomal dominant

Mutation: polyglutamine repeat

Can lead to dementia and Choreiform movements.

26
Q

Pathology of huntingtons disease

A

Loss of GABA and cholinergic neurons. Specifically in cerebral cortex and corpus striatum.

27
Q

In schizophrenia younger patients show more pos or neg symptoms?

A

Young = more positive symptoms (hallucinations)

Old = more negative symptoms (apathy)

Gray matter loss in adolescents

28
Q

Schizophrenia environmental causes?

A

Maternal viral infection
Maternal famine/stress
Cannabis
Winter/spring birth

29
Q

Schizophrenia (Dopamine turnover hypothesis)

A

Schiz caused by inc. DA. Treat with DA antagonists and partial agonists.

30
Q

Mesolimbic pathway inc

A

Positive symptoms of schiz

31
Q

Mesocortical pathway inc

A

Negative symptoms

32
Q

Depression

A

High conc of plasma cortisol
Doesn’t fall following dexamethasone.

Corticotrophin releasing hormone high in sufferers.

33
Q

Pathology of depression

A

Neurone loss in hippocampus and pre frontal cortex.

Evidence: Ventricular enlargement. Hippocampal shrink. Prefrontal atrophy.

34
Q

Reversible MAO inhibitors

A

Moclobemide

35
Q

Irreversible MAO inhibitors

A

Phenelzine