Week 7 - Drugs Flashcards
S/E of oestrogen blockade (Tamoxifen and Aromatase Inhibitors)
Hot flushes
What drug can be given to alleviate the hot flushes women can get from as a side effect from their oestrogen blockade
Clonidine
What form of contraception is CI if a woman has breast cancer
Merina Coil
If a women with breast cancer gets bone mets, what treatment can be given?
Bisphosphonates
S/E Tamoxifen
Vaginal bleeding
Endometrial hyperplasia and cancer
Polyps
Anti-depressants are contraindicated if a woman with breast cancer is receiving treatment with aromatase inhibitors - T/F?
F.
Anti-depressants are CI with TAMOXIFEN
If a woman is on the pill, why might this put her at a higher risk of developing fibroadenoma?
Because fibroadenoma is oestrogen dependent
What treatment can you give to women with ER+ve
Anti-oestrogen therapy:
Tamoxifen
Aromatase Inhibitors (Letrozole)
GnRH antagonists (drugs with a name ending in ‘-lix’
What treatment could you give to a women with HER2+ breast cancer
Trastuzumab
Most effective neo-adjuvant to achieve breast conservation?
Aromatase Inhibitors (more effective than tamoxifen)
Give one advantage and one disadvantage of artificial implants compared to self-tissue flaps for breast reconstruction.
Adv- Quicker recovery time
Disadv - more prone to problems in the future
Radiotherapy can be used as a neo-adjuvant - T/F?
F.
It can only be used as an ADJUVANT therapy
Why does chemo cause axial skeletal pain?
It causes bone marrow stimulation
