Wed Renal Pathology

Question 1

What is the main microscopic finding in autosomal recessive polycystic kidney disease?

when does it present

Answer 1

autosomal recessive presents in childhood (AD in ADult)

micro findings: dilation of all collecting tubules

Question 2

In autosomal recessive PCKD, if they survive infancy, what else do you see

Answer 2

liver cysts, hepatic fibrosis, periportal fibrosis

bile duct proliferation

Question 3

what is a common cause of acquired cystic kidney disease

Answer 3

dialysis

Question 4

in primary glomerulonephritis, what complement is responsible for activating neutrophils

Answer 4

C5 activates neutrophils which cause nephritic syndrome

Question 5

when do you see BIG subepithelial deposits in the kidney

Answer 5

PSGN

poststreptococcal glomerularnephritis

Question 6

what type of kidney condition is characterized by spikey deposits right next to the podocytes? (epitheliam deposits)

Answer 6

membranous nephropathy

Question 7

what kidney disease is characterized by immune complex deposits inside the basement membrane?

Answer 7

memnbranoproliferative GN

or SLE

Question 8

if you have deposits in the mesangium of the glomerulus what are you thinking

Answer 8

IgA nephropathy

HSP
bergers

Question 9

when would you see actual thickening of the BM in the kidney

Answer 9

DM - glycosylation

antibody deposits

Question 10

if you see crescents in the glomerulus what are you thinking for diseases and what are the crescents composed of

Answer 10

rapidly progressive glomerulonephritis (goodpastures, post strep, diffuse proliferative, wegeners, microscopic polyangiits, churg-straus)

crescents are composed of fibrin and macrophages

Question 11

smokey urine in a kid who feels sick =

Answer 11

acute poststrep GN

Question 12

periorbital edema = what are you thinking

Answer 12

acute poststrep GN