WBC disorders

Question 1

Hematopoietic stem cell are CD ____

Answer 1

CD 34+

Question 2

Hematpoitic stem cell can develop into (2)

Answer 2

myeloid , lymphoid stem cells

Question 3

Myeloid stem cells can form what (4) cells

Answer 3

Erythroblasts , myeloblast(Neutro, Baso,Eosino) Monoblast, Megakaryoblast

Question 4

lymphoid stem cell can form what

Answer 4

b lymphoblast and t lymphoblasts

Question 5

Low WBC count

Answer 5

less than 5K

Question 6

high WBC count

Answer 6

more than 10K

Question 7

neutropenia

Answer 7

decrease number of neutrophils

Question 8

two causes of neutropenia

Answer 8

drug toxicity and severe infection (gram - sepsis)

Question 9

treatment for neutropenia

Answer 9

GM-CSF or G-CSF

Question 10

what is lymphopenia

Answer 10

decreased number of circulating lymphocytes

Question 11

name the four causes of lymphopenia

Answer 11

immunodeficiency , high cortisol state , auto immune destruction, whole body radiation

Question 12

name the two causes for leukocytosis

Answer 12

bacterial infection/tissue necrosis , high cortisol state

Question 13

most susceptable to whole body radiation

Answer 13

pymphocytes

Question 14

monocytosis refers to

Answer 14

increased circulating monocytes

Question 15

causes of monocytosis

Answer 15

chronic inflammatory state and malignancy

Question 16

what is characteristic of young neutrophils from mature neutrophils

Answer 16

decrease number of Fc receptors on immature neutrophils , decrease phagocytosis ability

Question 17

with leukocytosis how does the bone marrow react

Answer 17

ups if WBC production “left shift”

Question 18

CD16 is a marker for what about neutrophils

Answer 18

maturity, decreased CD16 = Decreased Fc receptor meaning immature neutrophils

Question 19

High cortisol state can cause

Answer 19

leukocytosis

Question 20

neutrophils exist in two groups where are these groups located

Answer 20

marginated pool attached to endothelium ,

and circulating neutrophils in the serum

Question 21

mechanism for leukocytosis with a high cortisol state

Answer 21

cortisol disrupts neutrophil attachment to endothelium , causing inc lvl of blood neutrophils

Question 22

eosinophilia is caused by (3)

Answer 22

allergic reactions (hypersensitivity) , parasitic infections, hodgkin lymphoma

Question 23

increased eosinophilia is mediated by what chemotactic factor

Answer 23

IL-5 , seen in hodgkin lymphoma

Question 24

basophilia is seen in

Answer 24

CML ( chronic myeloid leukemia )

Question 25

lymphocytics leukocytosis has two main causes

Answer 25

viral infections and bordetella pertussis infection

Question 26

bordetella pertussis infection produces (bacterial)

Answer 26

lymphocytosis promoting factor

Question 27

lymphocytosis promoting factor effects lymphocytes by

Answer 27

blocking them from entering the lymph node or from leaving the blood

Question 28

INfectious mononucleosis most commonly caused by

Answer 28

EBV infection

Question 29

EBV is referred to as the _____ disease

Answer 29

Kissing disease

Question 30

what symptoms would you expect with a patient infected with EBV

Answer 30

pharyngitis , hepatitis(hepatomegaly) elevated liver enzymes