W2- Lecture 11-Protein secretion Flashcards
Name two types of secretion
+ what cells do this
Constitutive secretion - by all cells continually exporting so substances
Regulated secretion- specialised secretory cells + substances stories in vesicles
Where are proteins translated + modified?
ER
Which organelle helps transport proteins to their final destination ?
Golgi
Label a Golgi apparatus
Cis face- entry
Trans face - exit
Cisternae- sausage things
Lumen - inside of sausages
What proteins are involved in the conventional secretory pathways ?
Sec proteins
What enzymes are involved in lysosomal/ Phagosomal pathways ?
VPs
By what process multiple vesticular bodies (MVB)produced by ?
Endocytosis
What is produced when a autophagosome and an MVB fuse together ?
Amphisome
What cells within the pancreas are endocrine components ?
+where can they be found ?
Islets of langerhans
Found in the Tail of the pancreas
What three types of cells are found in the Islets of langerhans?
+ what they secrete
Alpha-glucagon secreting cells
beta ß- insulin secreting cells
Delta ∆-somatostatin secreting cells
In the pancreas what do the acinar cells secrete ?
Digestive enzyme e.g trypsin
produced as ion active
What is an inactive enzyme often know as ?
Zymogen
What are the main characteristic characters of a pancreatic acinar cells ?
Large amounts of RER
Large amounts of secretary granules
Very ordered cytoplasmic structure (act as storage )
Describe the six step process from initiation of protection synthesis to exocytosis
- initiation of protein synthesis
- synthesis segregated from cytosolic proteins
- processing of proteins
- packaging and condensing
- storage in vesicles
- released via exocytosis
Where are secretory proteins synthesised ?
On ribosomes attached to the ER
