Vitamins and Deficiencies Flashcards
Fat soluble vitamins
A, D, E, K
Water soluble vitamins
All of the B’s (thiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, cobalamin), C
Vitamin A Deficiency
Night blindness (nycatlopia)
dry, skaly skin (xerosis cutis)
corneal degeneration (keratomlaacia)
immunosuppression
Vitamin A Excess
Acute toxicity = nausea, vomiting, vertigo, blurred vision
Chronic toxicity = alopecia, dry skin, hepatotoxicity, arthralgias, pseudotumor cerebri
Teratogenic, so negative pregnancy test is required for isotretinoin management
Vitamin B1 is also known as…
thiamine
Vitamin B1 deficiency
Thiamine deficiency
Impaired glucose breakdown leads to ATP depletion
- Wesicke-Korsakoff syndrome: confusion, ophthalmoplegia, ataxia; confabulation, personality changes, memory loss (permanent) - damage of medial dorsal nucleus of thalamus, mammillary bodies
- Dry beriberi: polyneuritis, symmetrical muscle wasting
- Wet beriberi: high-output cardiac failure (dilated cardiomyopathy), edema
Vitamin B2 is also known as…
riboflavin
Vitamin B2 deficiency
Cheilosis (inflammation of lips, scaling and fissures at corner of mouth)
Corneal vascularization
Vitamin B3 is also known as…
niacin
Vitamin B3 deficiency
Glossitis
Severe deficiency can lead to pellagra, particularly in setting of Hartnup disease (decreased tryptophan absorption), malignant carcinoid syndrome (increased tryptophan metabolism), or isoniazid (decreased vit B6)
Symtpoms of pellagra: diarrhea, dementia (and hallucinations), dermatitis (particularly in C3/C4 dermatome) with hyperpigmentation of sun-exposed limbs
Vitamin B3 Excess
facial flushing - incudec by prostaglandin
hyperglycemia
hyperuricemia
Vitamin B5 Deficiency
Dermatitis, enteritis, alopecia, adrenal insufficency
Vitamin B5 is also known as
panthothenic acid
Vitamin B6 is also known as
pyridoxine
Vitamin B6 Deficiency
Convulsions, hyperirritability, peripheral nueropathy, sideroblastic anemias due to impaired hemoglobin synthesis and iron excess