Viruses Flashcards

1
Q

virus particles are called

A

virions

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2
Q

virions are composed of DNA or RNA and are encased by a protein coat called

A

capsid

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3
Q

what surrounds the capsid protein coat

A

lipoprotein envelope

or nothing if naked

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4
Q

how do you examine viruses

A

electron microscope

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5
Q

virions can only replicate where

A

inside a living cell

obligate intracellular parasites

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6
Q

how are viral capsids classified

A

helical
icosahedral
complex

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7
Q

what is function of capsids

A

protect genome
receptors to initiate infection
stimulate antibody production
antigen determinant

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8
Q

what refers to capsid and the viral genome together

A

nucleocapsid

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9
Q

what is located within the envelope

A

viral specific glycoproteins

VSG

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10
Q

what is the importance of viral specific glycoproteins VSG

A

how enveloped viruses initiate infection

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11
Q

what are the steps in a viral infection

A

attachment - viral attachment proteins attach to receptors on host

penetrate - receptor mediated endocytosis or viropexis

uncoating - capsid separates from genome and duplicates

budding - duplication of genome proteins and accumulation of virus inside cell and then virus leaves by budding out

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12
Q

what are examples of killed vaccines

A

polio vaccine (salk)
rabies vaccine
influenza vaccine
hepatitis A vaccine

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13
Q

how are killed vaccines made

A

heat or chemicals kill viruses and then patient given vaccine

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14
Q

what are different way to make vaccine

A
live virus 
killed virus 
virion subunits 
viral polypeptides 
viral DNA
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15
Q

live vaccines are ___ viral strains

A

attentuated

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16
Q

what are examples of live vaccines

A
measles 
mumps 
rubella 
chickenpox 
rotavirus 
yellow fever 
adenovirus