Virulence factors and bugs

Question 1

Adhesin-like surface-associated proteins (AgI/II)

Answer 1

Capable of binding to receptors in pellicle. Mutans streptococci have this

Question 2

Extracellular glucosyltransferases (Gtfs)

Answer 2

Constituents of pellicle and are capable of synthesizing glucans in situ from glucose. Provide large additional binding sites for S. mutans

Question 3

Urease

Answer 3

Raises the pH to allow H. pylori to make it through layer with very low pH

Question 4

Motility

Answer 4

Flagella allows for H. pylori to move through low pH layer

Question 5

Chemotaxis

Answer 5

Sensors allow H pylori to move closer to area of higher pH

Question 6

Adherence factors (for H. pylori)

Answer 6

Allow some cells to avoid mechanical clearance, promotes invasion and persistence, activity of adhesins contributes to inflammation

Question 7

VacA

Answer 7

H. pylori, pore forming cytotoxin that allows leakage of Ca++ from epithelial cell

Question 8

CagA

Answer 8

Travels into the host cytosol and affects the proliferative activities, adhesion and cytoskeletal organization of epithelial cells. Highly proinflammatory.

Question 9

H. pylori characteristics

Answer 9

Bacteria– gram (-) –flagellated helix-shaped rod (spirilli)–microaerophilic–catalase and oxidase + – Urease +

Question 10

EBV

Answer 10

Herpesviridae– double stranded – linear – DNA – enveloped – Human herpesvirus 4

Question 11

Candida albicans

Answer 11

Fungus– hyphael forms – bacilli – non-spore forming – non-motile

Question 12

Strep. pyogenes

Answer 12

Bacteria– gram(+) – cocci – catalase (-) – Beta hemolytic – Bacitracin sensitive

Question 13

Corynebacterium diphtheriae

Answer 13

Bacteria – gram (+) – bacilli – non-spore forming – non-motile

Question 14

Streptococcus mutans

Answer 14

Bacteria– gram (+) – cocci – catalase negative – facultative anaerobe – alpha hemolytic – optochin resistant