Viral vaccines Flashcards
Vaccine used by Jenner when he introduced concept of vaccination
Cowpox against smallpox
What is the difference between the immunity induced by a live, attenuated virus and that of killed virus vaccines?
Live, attenuated vaccines induce humoral and cell-mediated immunity whereas killed vaccines induce only humoral immunity
What is the advantage of killed vaccines over live, attenuated vaccines?
Killed vaccines are more stable, whereas live, attenuated vaccines have reverted to virulence on very rare occasions
Live vaccines are dangerous to give to which populations?
Immunocompromised patients or their contacts
Live attenuated vaccines
- Sabin polio virus
- MMR
- Yellow fever
- Rotavirus
- Influenza (intranasal)
- Chickenpox (VZV)
- Smallpox
Memory aid:
Some music and LYRICSS are best enjoyed live!
Name four killed virus vaccines
- Rabies
- Influenza (injected)
- Polio (Salk)
- HAV
- Memory aid:*
- RIP _A_lways
Subunit vaccines (recombination vaccines)
- HBV (antigen = HBsAg)
- HPV (types 6, 11, 16, and 18)
What is the antigen that is present in the hepatitis B virus vaccine?
Recombinant hepatitis B surface antigen
Which human papillomavirus types does the human papillomavirus vaccine protect against?
What is the only live, attenuated vaccine that can be given to HIV-positive individuals?
MMR (measles, mumps, rubella)
