viral chemotherapy Flashcards
1
Q
what are the main types of antiviral drugs?
A
- attachment inhibitors
- penetration inhibitors
- genome replication inhibitors
- gene expression inhibitors
- assembly inhibitors
2
Q
what is meant by ‘chemotherapeutic index’?
A
[drug] inhibits virus rep/[drug] toxic to host.
want a drug that is more toxic to virus than host
3
Q
which phase of infection do the drugs amantadine and rimantadine target?
A
penetration and uncaring in influenza A
4
Q
what kind of drug is aciclovir?
A
a drug that targets virus polymerase. it is a pro-drug and must be activated by phosphorylation
5
Q
what type of drug is raltegravir Isentress?
A
HIV integrase inhibitor
6
Q
why is gene expression a bad target?
A
viruses are dependent on the HOST cellular machinery for transcription, mRNA splicing etc. would be toxic to the host
