Uterine Malignancy EZ Flashcards
Possible cause of endometrial hyperplasia
Oestrogen stimulation
Atypical hyperplasia is the precursor for which type of cancer
Endometriod cancer
Serous intraepithlial carcinoma is the precursor for which type of cancer
Serous cell carcinoma
If a young person gets endometrial carcinoma, what underlying conditions should you consider?
PCOS
Lynch syndrome
Most endometrial carcinomas are which type of cancer?
Adenocarcinoma
Why is obesity linked with endometrial cancer?
Adipocytes convert ovarian androgens into estrogens
Lynch syndrome increases risks of which types of cancer?
- colorectal
- ovarian
- endometrial
Lynch syndrome inheritence
Autosomal dominant
How can you identify tumours due to Lynch syndrome
Immunohistochemistry staining for mismatch repair proteins
-you can also test cancer tissue for microsatellite instability
Endometrial stromal sarcoma arises from where?
Arises from the endometrial stroma
-they infiltrate the myometrium and often the lymphovascular spaces
This is a mixed tumour with malignant, epithelial and stromal elements
Carcinosarcoma
How do endometrial stromal sarcomas present?
Often present with abnormal uterine bleeding but can present as metastases (usually ovary or lung)
Most important prognostic factor in endometrial stromal sarcoma?
Stage
endometrial carcinoma prognosis depends on stage, histological grade and depth of myometrial invasion
The presence of a rhabdomyosarcomatous component in a carcinosarcoma has what kind of prognosis?
The worst prognosis
This smooth muscle tumour is associated with menorrhagia and infertility
Leiomyoma
