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Pathophysiology > Unit 2: Review of Immune Function > Flashcards

Unit 2: Review of Immune Function Flashcards

1
Q

Thoracic Duct

A

Empties into L subclavian vein, largest

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2
Q

R Lymphatic Duct

A

Empties into R subclavian vein

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3
Q

What type of lymph node does Outer Cortex produce?

A

B lymphocytes

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4
Q

What type of lymph node does paracortex produce?

A

T lymphocytes

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5
Q

What type of lymph node does medulla produce?

A

Efferent lymphatic & lymphocytes

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6
Q

Red pulp (spleen)

A

removes/recycles RBC
stores iron
stores platelets

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7
Q

White pulp (spleen)

A

Stores B& T lymphocytes

Monitors blood for Ag recognition

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8
Q

T- cells

A

cell-mediated immunity

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9
Q

B-cells

A

antibody-mediated immunity

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10
Q

NK cells

A

natural killer

innate immunity

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11
Q

Macrophages & dendritic cells

A

antigen presentation

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12
Q

C3b

A

Opsonin

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13
Q

C5a

A

chemotaxis

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14
Q

C3a/C5a

A

anaphylatoxins

inflammation

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15
Q

C5b

A

MAC to punch holes in pathogen membranes

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16
Q

CD3+, CD 28+

A

general t cell markers

17
Q

CD8+

A

cytotoxic T cells

NK cells

18
Q

CD4+

A

Helper T cells

19
Q

CD4+, CD 25+

A

Regulatory or Suppressor T cells

20
Q

Class I MHC

A

HLA- A
HLA- B
HLA - C

21
Q

Class II MHC

A

HLA - DQ
HLA-DP
HLA-DR

22
Q

Interleukin 1

A 
Causes T cell division
Increases neutrophils
Acute phase rxn
Fever & fatigue
Granuloma formation
23
Q

Interleukin 2 (t-cell growth factor)

A

Produced by activated t-helper cells

Causes t-cell divison

24
Q

Interleukin 5

A

Produced by activated t-helper cells

Increases eosinophils

25
Q

Interleukin 8

A

Produced by macrophages

chemotactic for neutrophils

26
Q

Interferons

A

Interfere with viruses and other actiities

27
Q

Beta interferon

A

Activates B cells to plasma cells

28
Q

Gamma interferon

A

activates macrophages & increases MHC 2 expression

29
Q

TNF/Cahchectin

A 
Produced by t-cells, macrophages
Causes inflammation
Causes acute phase rxn
Fever
Induce apoptosis on tumor cells
30
Q

IgM

A

Responsible for rapid destruction of incompatible blood types

31
Q

IgG

A

Responsible for resistance against many pathogens & toxin
Can cross placenta

32
Q

IgA

A

Found in glandular secretions
Secreted to the apical surface
Bind pathogens before they enter body

33
Q

IgD

A

Acts as b-cell receptor

Sensitizes B cells

34
Q

IgE

A

On surfaces of basophils & mast cells

Causes histamine rxn to initiate inflammation

Pathophysiology (5 decks)

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