Type 1 hypersensitivity Flashcards
What is type 1 mediated by
IgE mediated
Examples of type 1 hypersensitivity reactions
Allergies, hives, eczema, allergic rhinitis and asthma
What is an allergen
Antigen that causes allergic reaction
Where do antigen presenting cells present allergens and what do they present it to
Lymph nodes and naive helper t cells
Examples of antigen presenting cells
Macrophages and dendritic cells
What, along with the allergen, do antigen presenting cells present
Co-stimulatory molecule
What do naive helper t cells become once they bind to the allergen and co-stimulatory molecule
Primed helper T cells
In response to which interleukens does primed helper t cell become Th2 cells
IL 4,5 and 10
What interluekin do Th2 cells release and what effect does it have on B cells
IL-4 and causes B cells to stop producing IgM and produce IgE
What interleukin do Th2 cells release that have an effect on eosinophils and what is the effect
IL-5 and stimulates the production and activation of eosinophils. Eosinophils the release toxic substance to destroy allergens
What receptors on mast cells do IgE bind to
Fce receptors
What cell produces pro-inflammatory mediators during the early sensitization stage
Mast cells
Treatment for type 1 hypersensitivity reactions
Antihistamines, corticosteroids and epinephrine.
