Tumours: Adenoma

Question 1

They are benign tumours of the ___ cells or ___ tissue

Answer 1

They are benign tumours of the columnar cells or glandular tissue

Question 2

They are non- invasive and do not _____ however, they are known to be precursors for ______ and this is why they are ____

Answer 2

They are non- invasive and do not metastasise however, they are known to be precursors for adenocarcinoma and this is why they are removed

Question 3

their microscopic architecture can be ___, ____ or a mix (____)

Answer 3

tubular, villous or tubulovillous

Question 4

The tubular one contains___ ____ arising from a ____ surface

Answer 4

The tubular one contains tubular crypts arising from a lobulated surface

Question 5

The villous has a small-intestine like velvety surface made up of __

Answer 5

The villous has a small-intestine like velvety surface made up of vili

Question 6

Most adenomas are not inherited, true/false?

Answer 6

true - termed sporadic adenomas

Question 7

adenoma is dysplastic and adenocarcinoma is _____

Answer 7

invasive

Question 8

adenoma - carcinoma sequence

1. mutation and/or loss of the ___ ____ ____ gene is an early event in adenoma development
2. mutational activation of the __-___ _______ and loss of the-____ arm of chromosome ___ are important events in increasing _____ of adenomas
3. mutation and/or loss of the ____ ____ ___ ___ and ____ is associated with progression from ___ to -___ .

Answer 8

1. mutation and/or loss of the adenomatous polyposis coli (APC) gene is an early event in adenoma development
2. mutational activation of the K-ras oncogene and loss of the long arm of chromosome 18 are important events in increasing growth of adenomas
3. mutation and/or loss of the p53 tumour suppressor gene and 18q is associated with progression from adenoma to carcinoma.

Question 9

does size matter with adenomas?

Answer 9

yes

Question 10

which is lower risk for progressing to carcinoma, villous or tubular? and also sessile or flat?

Answer 10

villous and sessile more malignant

Question 11

Not all colorectal adenomas have the same molecular genetic origins
which are the tumours with separate pathways ?

Answer 11

inherited tumours and serrated adenomas