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Cancer LCRS > Tumour Suppressor Genes > Flashcards

Tumour Suppressor Genes Flashcards

1
Q

List seven TSG

A 
APC
p53
BRCA1 
Rb
PTEN
MLH1
P16INK4A
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2
Q

What does BRCA1 do?

A

Cell cycle regulation

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3
Q

Where does the product of BRCA1 act?

A

Nucleus

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4
Q

Which cancers are BRCA1 implicated in?

A

Breast, ovarian, prostate

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5
Q

What is the product of PTEN?

A

Lipid and tyrosine phosphatase

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6
Q

Where does the product of PTEN work?

A

Cytoplasm

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7
Q

Which cancers are PTEN implicated in?

A

Prostate

Glioblastoma

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8
Q

Which pathway is APC involved in, and what is its target?

A

WNT signalling - Beta catenin

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9
Q

What does the product of MLH1 do?

A

DNA mismatch repair

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10
Q

Which cancers are MLH1 implicated in?

A

Colon

Gastric

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11
Q

What does the product of p16INK4A do?

A

Regulates cell cycle

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12
Q

Where does the product of p16INK4A act?

A

Nucleus

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13
Q

P16INK4A is implicated in which cancers?

A

Colon

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14
Q

Which TSG are implicated in colon cancer?

A

APC
MLH1
P16INK4A

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15
Q

Which two TSG are implicated in prostate cancer?

A

BRCA1

PTEN

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16
Q

Which TSG is implicated in glioblastoma?

A

PTEN

17
Q

Name a TSG involved in gastric and colon cancer

A

MLH1

18
Q

What is the function of the Rb protein?

A

Controls transcription and cell cycle proliferation

19
Q

Where does p53 act?

A

Nucleus

20
Q

What inactivates p53?

A

MDM2 (or HDM2)

21
Q

What is the function of p53?

A

Regulates cell cycle

22
Q

What are TSG?

A

Genes which regulate cellular proliferation and maintain cell integrity

23
Q

What are some characteristics of TSG related cancers?

A

Tumours are often bilateral

Can be inherited

24
Q

Explain the mutation hypothesis behind:
inherited cancer
sporadic cancer

A

Inherited - 1 inherited mutation, 1 acquired mutation

Sporadic - 2 acquired mutations

25
Q

Which gene is mutated in retinoblastoma?

A

RB1

26
Q

On which chromosome is RB1?

A

13q14

Cancer LCRS (10 decks)

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