Toxic Epidermal Necrolysis

Question 1

Toxic Epidermal Necrolysis is a life threatening skin disorder that is most commonly seen secondary to a [Blank}

Answer 1

Drug reaction

Question 2

How does TEN relate to erythema multiforme and Stevens-Johnson syndrome?

Answer 2

It is at the severe end of the spectrum of erythema multiforme and Stevens-Johnson syndrome.

Question 3

What is the Nikolsky’s sign?

Answer 3

It is where the epidermis separates with mild lateral pressure

Question 4

What drugs cause Toxic Epidermal Necrolysis?

Answer 4

• Phenytoin
• Sulphonamides
• Allopurinol
• Penicillins
• Carbamazepine
• NSAIDs

Question 5

How is Toxic Epidermal Necrolysis managed?

Answer 5

• Stop precipitating factor
• Supportive care, often in intensive care unit
• Intravenous immunoglobulin has been shown to be effective and is now commonly used first-line
• Other treatment options include: immunosuppressive agents (ciclosporin and cyclophosphamide), plasmapheresis