Topic 51 Flashcards
Riboflavin (B2) deficiency (etiology)
-malnutririon
-malabsorbtion
-alcoholism
-conditions, leading to protein malnutrition
(children not consuming any milk)
Riboflavin (B2) deficiency (symptoms)
- Seborrheic dermatitis: * skin
- face
- nasal apertures
- nasolabial folds
Riboflavin (B2) deficiency (oral symptoms)
- angular cheilitis:
in the beginning: yellowis, scaly crusts on the corner of the mouth, then they become red, deep, painfull fissures
(pebbly appearance),
they bleed easily - Tongue: atrophic, magenta in colour, painfull, fissured
Riboflavin (B2) deficiency (differential diagnosis)
-anemia caused by
iron deficiency
-chronic atrophic
candidiasis
Riboflavin (B2) deficiency (therapy)
- riboflavin
Nicotinamide (B3) deficiency-pellagra
etiology
- protein malnutrition
- anacidity
- gastroenteritis
- congenital metabolic disorders
- chronic alkoholism
Nicotinamide (B3) deficiency-pellagra
symptoms
- loss of appetite
- weakness
In more evolved cases: - dermatitis
- dementia
- diarrhea
Nicotinamide (B3) deficiency-pellagra
oral symptoms
Tongue:
- atrophic filiform papillae
- swollen
- painful
- burning
- red, resembles „raw meat”
Nicotinamide (B3) deficiency-pellagra
differential diagnosis
- pernicious anaemia
- anaemia caused by
iron deficiency - Sjögren’s sy.
Nicotinamide (B3) deficiency-pellagra
therapy
- Substitution of
nicotinic acid
Folic acid (B6) deficiency (etiology)
- imbalanced nutrition (vegetables and fruits) - malabsorption (celiac disease) - alcoholism - anorexia - cancerous disease - pregnancy - hemolytic anaemia - medication (contraceptives, phenytoin, anticonvulsive drugs) - accompanied by the lack of vit. B12 - The lack of folic acid demages protein synthesis and cell division
Folic acid (B6) deficiency (symptoms)
- erythemas
- atrophic, painful tongue
(filiform, fungiform papillae disappear) - aphtous ulcers
- angular cheilitis
Folic acid (B6) deficiency (diagnosis)
- serum folic acid and B12 levels
Folic acid (B6) deficiency (differential diagnosis)
- Anaemia
- Other B vit. deficiencies
Folic acid (B6) deficiency (therapy)
- substitution of folic acid and B12
- local symptomatic treatment
Vitamin C deficiency-scurwy
etiology
- insufficient nutrition
(poverty, elderly age, chronic alcoholism)
1. In infancy or chilhood: Möller-Barlow disease
-disturbances of bone development
2. In adults
-demaged collagen synthesis
-failed connective tissue regeneration
Vitamin C deficiency-scurwy
symptoms
- hyperkeratotic hair follicule
- perifollicular bleeding
Vitamin C deficiency-scurwy
oral symptoms
- swollen gingiva
(cover the crown) - easy or spontaneusly
bleeding gingiva - pain of mandibular bones
- gingiva necrosis around bleeding area
- accompany oral odor and fusospirochaetal stomatitis
(cause swift destruction of alveoli and loss of teeth) - patients without teeth have not oral symptomes except bleeding
- ulcerativ stomatitis (also by patient without teeth
- TMJ haemorrhage
Vitamin C deficiency-scurwy
diagnosis
- Rumpel-Leede sign is positive
Vitamin C deficiency-scurwy
differential diagnosis
- ulcerative, necrotising,
herpetic gingivostomatitis - leukaemia
- agranulocytosis
Vitamin C deficiency-scurwy
therapy
- ascorbic acid
