Tissue engineering Flashcards
What is tissue engineering
An interdisciplinary field that applies the principles of engineering and life sciences to restore, maintain, or improve tissue function or a whole organ.
Who are the pioneers articles for tissue engineering
- Robert Langer
- Joseph Vacanti
What is Vacanti Mouse
- Grow an ear on the back of the mouse
Paradigm of Tissue Engineering
- Cells harvested from the patient
- Expanding cells.
- Cells seeled on the scaffold
- Construct with cells in scaffold cultured.
- Construct implanted in the patient.
Three major components of Tissue Engineering
- Cells source
- Scaffolds
- Biological Factors
What are some common cell source for TE
- Autograft, Xenograft, Allograft
- Stem cells
Advantage and disadvantage to use autologous cell
- Adv: no rejection or disease transmission
- Dis: limited quantity, costly, time delay for expansion
Adv and disadv of xenologous and allologous cells
- Adv: Unlimited quantity, less expensive
- Dis: disease transmission, immune rejection
Adv of stem cells
- Self-renewable and differentiate.
Why is scaffold important for tissue engineering
- Because it gives the cells structural support to attach on and grow
What is ECM
- Extra cellular matrix (3D structure)
Relationship between ECM and cells
- Provides structural support
- Regulates biological functions
- Has many cross-linked proteins.
What is native ECM
- When cells are decellularize out
- Biocompatible and biodegradable.
Tissue engineering companies in Texas
- SmithNephew
- Biotechnology
