Test 2 Flashcards
Three locations of UTIs
urethra- urethritis
bladder- cystitis
upper urinary tract- pyelonephritis
Symptoms of an acute simple cystitis lack what symptoms?
fever >99.9
systemic symptoms- chills or body aches
flank pain
costovertebral angle tenderness (CVA)
Microbiology of UTIs
75-95% of cases are E.Coli
Other organisms: enterobacteriaceae, klebsiella pneumoniae, proteus mirabilis, and staphlococcus saprophytcus
Clinical manifestations of UTI
urinary frequency, urgency, hesitancy, dysuria, suprapubic pain, hematuria
Specific manifestation of UTI in older adults
new onset nocturia, incontinence, forgetfulness, new or worsening urinary symptoms
Physical exam for UTI
not necessary but if performed should include CVAT, abdominal, fever assessment
Pelvic exam if vaginal complaints
Lab results positive for UTI
leukocytosis >10 microL
nitrates and + leaks on dipstick or UA
Urine culture if resistant organisms or all cases of upper UTI
What do you do for a negative urine dipstick test?
urine culture and/or UA due to high rate of false negatives
Multiple organisms on urine culture indicates…
suspected contamination
Treatment of UTI
first line: nitrofurantoin, trimethoprim-sulfamethoxazole, fosfomycin
OTC treatment for urinary discomfort
phenazopyridine
When should you expect symptom relief for a properly treated UTI
48-72 hours
Nonpharmacological treatment of UTI
liberal fluid intake (2-3L per day)
behavior modification- contraception modification, postcoital voiding, good hygiene
cranberry juice/pills (limited studies)
Etiologies for volvovaginitis
infection
reactions to allergens or irritants
estrogen deficiency
systemic disease (RARE)
Normal vaginal discharge physiology
white or transparent, thick, mostly odorless
formed by mucoid endocervical secretions with sloughing epithelial cells, normal bacteria, and vaginal transudate
Normal pH of vaginal secretions
4.0-4.5 (acidic)
In premenarchal and postmenopausal women: 4.7 or greater
Normal isolates of vagina
most abundant is lactobacillus
Bacterial Vaginosis (BV) findings
thin, off white discharge with fishy odor
no vaginal inflammation
pH >4.5
clue cells present
positive whiff test
Candidiasis findings
itching, soreness, change in discharge, “cottage cheese” discharge
vaginal inflammation
normal pH
pseudohyphae
budding yeast
negative whiff test
Trichomoniasis findings
malodorous, thin, yellow-green, frothy purulent discharge
vaginal inflammation
pH >4.5 motile trichomonads
often positive whiff test
Symptoms of vaginitis
change in volume, color, or odor of vaginal discharge
pruritus
irritation
burning
soreness
erythema
dyspareunia
spotting
dysuria (less common)
Rare findings of vaginitis
abdominal pain (think PID)
suprapubic pain (think cystitis)
Common diagnosis based on menses cycle
candida vulvovaginitis often in premenstrual period
trichomoniasis and BV often during or immediately after menstrual period
Pelvic exam should include…
degree of vulvovaginal inflammation
characteristics of vaginal discharge
presence of cervical inflammation
abdominal or cervical motion tenderness
Can appearance of vaginal discharge be used for diagnosis
NO.. extremely unreliable
What is the most important finding for diagnostic process of vulvovaginitis
pH… should always be determined
Cervical inflammation is suggestive of…
cervicitis
In cervicitis the cervix will be
erythematous and friable with a mucopurulent discharge
Ectropion
represents normal physiologic presence of endocervical glandular tissue in the exocervix. not friable
Lab tests to diagnose vulvovaginitis
narrow range pH paper or broad range paper
saline microscopy- performed 10-20 minutes from obtaining sample
Technique of saline microscopy
vaginal discharge sampled with cotton-tipped swab
sample is mixed with one to two drops of 0.9% NS on a glass slide
cover slips placed on slides which are examined under a microscope at 10x and 40x
KOH preparation for microscopy
addition of 10% potassium hydroxide (KOH) destroys cellular elements and can be helpful in diagnosis (especially candida vaginitis)
whiff test is used with KOH
excessive WBCs without evidence of yeast, trichomonads, or clue cells suggests cervicitis
Most common cause of vaginitis in women of childbearing age
Bacterial vaginosis
Diagnosis of bacterial vaginosis is made when 3 of the following are present
abnormal grayish discharge
pH greater than 4.5
+whiff test
presence of clue cells
Treatment of Bacterial Vaginosis
Metronidazole oral x 7 days
metronidazole gel intravaginally x 5 days
clindamycin gel intravaginally x 7 days
Alternatives: clindamycin oral x 7 days
clindamycin ovules intravaginally x 3 days
Most common cause of vulvovaginal itching
candida vulvovaginitis
90% are Candida albicans
Diagnosis and treatment of uncomplicated candida vulvovaginitis
sporadic, infrequent episodes
mild to moderate signs/symptoms
probable infection with candida albicans
healthy, non pregnant women
variety of OTC oral and vaginal regimens
oral prescription fluconazole may be less expensive than OTC options
Diagnosis and treatment of complicated candida vulvovaginitis
poorly controlled diabetes, immunosuppression, debilitation
severe signs/symptoms
candida species other than C. albicans (c. glabrata)
pregnancy
history of recurrent vulvovaginal candidiasis
oral fluconazole (150mg orally) for two to three doses 72 hours apart
eliminate risk factors
Organism responsible for trichomonas vaginalis
flagellated protozoan trichomonas vaginalis
Signs/Symptoms of Trichomonas Vaginalis
always sexually transmitted
purulent, malodorous, thin, frothy discharge, with associated burning, pruritus, dysuria, frequency, and vaginal inflammation
Diagnosis of trichomonas
presence of motile trichomonads on wet mount is diagnostic but only occurs in 50-70% of culture-confirmed cases
CULTURE is diagnostic
Treatment of Trichomonas vaginalis
Metronidazole or Tinidazole BID x 7 days
Also treat sexual partners
Etiology of genital ulcers
herpes simplex virus (MOST COMMON)
treponema pallidum
haemophilus ducreyi
klebsiella granulomatis (Rare in US)
lymphogranuloma venererum (unknown in US)
Painful ulcers, multiple lesions
think HSV, chancroid
Painless, single lesions
think syphillis, LGV, and granuloma inguinale
S/S of genital ulcers
dysuria
fever
malaise
body aches
lymphadenopathy
Diagnosis of genital ulcers
evaluate for herpes, GC, CT, screen for symphilis and HIV
viral culture (HSV)
serologic screening (syphillis)
Follow up of initial syphillis serology is negative
repeat 1-3 months later
Primary HSV infection
patient HSV-seronegative for both HSV-1 and HSV-2 prior to this episode
associated with multiple constitutional S/S
dysuria
sx can last 2-4 weeks if untreated
Non-primary HSV infection
in an area not previously infected
ex: oral then genital infection
Recurrent HSV
over time recurrence generally decrease and recurrence lower in HSV-1 vs HSV-2
recurrence may be asymptomatic, shorter in duration
Treatment of HSV (Primary infection)
Acyclovir
Famciclovir
Valacyclovir
Treatment of HSV (recurrent infection)
chronic suppressive therapy
episodic therapy
or nothing!
Acyclovir
Famciclovir
Valacyclovir
Organism responsible for syphilis
spirochete bacterium treponema pallidum
seen on dark field microscopy
corkscrew-shaped organism
Primary syphilis infection
chancre at site of entry approximately 10-60 days after infection
heals spontaneously in 3-6 weeks
Secondary syphilis infection
4-8 weeks after primary chancre appears, skin rash of rough red or brown lesions on trunk, palms, or soles
other symptoms: fever, lymphadenopathy, headache, weight loss, muscle aches, patchy hair loss
HIGHLY infective
if untreated resolves in 2-6 weeks and then enters latent phase (no symptoms but tests positive)
Tertiary stage of syphilis
1/3 of patients
transmission unlikely
mainly through transfusions or placental transfer
severe CNS and cardiovascular damage
ophthalmic and auditory abnormalities
gummas- 1-10 years
Diagnosis of Syphilis
Non-treponemal tests
VDRL
RPR
Treponemal tests
fluorescent treponema antibody absorption
microhemaglutination test for antibodies to T. pallidum
T. pallidum particle agglutination assay
T. pallidum enzyme immunoassay
Chemiluminescence immunoassay
USE of only ONE test is insufficient
Positive treponema test is positive for life
Treatment of syphilis
Early: benzathine Penicillin G IM once
Unknown duration: benzathine penicillin IM weekly for 3 weeks
Alternatives: Doxycycline 100mg PO BID for 4 weeks
Chancroid
starts as erythematous papule, evolves into pustule, erodes into a deep ulcer
almost always confined to genital area and draining lymph nodes
painful
base is usually covered with gray or yellow purulent exudate that bleeds when scraped
Diagnosis of Chancroid
definite- isolation of H.ducreyi bacteria from the lesion
probable- painful genital ulcer and tender suppurative inguinal adenopathy, plus negative dark field microscopic exam for T. pallidum, negative serum test for syphilis, negative culture for HSV, clinical presentation not typical for herpes
Treatment of chancroid
Azithromycin PO once OR ceftriaxone IM once
Alternatives: Ciprofloxacin or Erythromycin
Condyloma Acuminate
Genital warts
HPV manifestations
can be found on genitals, tongue, lips, oral cavity
spread through skin to skin contact
Patient applied treatments for condyloma acuminate
podofilox
imiquimod
sinecatechin
Healthcare applied treatments for condyloma acuminate
cryosurgery
trichloracetic acid
laser
intralesional interferon injections
Cervicitis
inflammation of uterine cervix
most common causes of Cervicitis
Chlamydia trachomatis and neisseria gonorrhoeae
Other causes of cervicitis
local trauma from foreign object
malignancy
radiation therapy
sensitivity to chemical irritation
systemic inflammatory disease
Clinical manifestations of cervicitis
may be asymptomatic
all sexually active women age 25 years or younger should be screened
cervix may be tender to motion
When present manifestations are:
purulent or mucopurulent discharge from the endocervix
intermenstrual or postcoital bleeding
dysuria, urinary frequency
dyspareunia
vulvovagnial irritation
Cardinal signs of cervicitis
purulent or mucopurulent discharge on the surface and/or exuding from the OS
friability (bleeding)
erythema and edema