Tema 4. Lipoproteínas Flashcards

1
Q

Transportan triglicéridos

A

Quilomicrones (exógenos) y VLDL (endógenos)

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2
Q

Transportan colesterol

A

HDL y LDL

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3
Q

Lipoproteín lipasa

A

Permite la liberación de los ácidos grasos de los QM, activada por la apo C2
Se localiza en el endotelio capilar

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4
Q

Los TG

A

No aumentan el riesgo cardiovascular

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5
Q

Cursan con RCV y xantomas tendinosos

A

Hipercolesterolemia familiar y el déficit de apoB 100

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6
Q

Las hipertrigliceridemias cursan con

A

Pancreatitis y xantomas eruptivos

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7
Q

Mixtas

A

Hiperlipemia familiar combinada (sin xantomas)

Disbetalipoproteinemia

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8
Q

Lipoproteína de mayor contenido proteico

A

HDL

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9
Q

ApoB48

A

Sintetizada en el intestino –> Quilomicrones

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10
Q

PCSK9

A

Degrada el receptor hepático de las LDL, impidiendo que sean captadas y eliminadas

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11
Q

inhiben PCSK9

A

Evolocumab y Alirocumab

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12
Q

Dislipemia primaria más frecuente

A

Hiperlipemia familiar combinada (AD)

No da xantomas, clínica de síndrome metabólico

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13
Q

Xantomas tuberosos y xantomas estriados

A

Disbetalipoproteinemia familiar, déficit ApoE

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