Task 7 Flashcards

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1
Q

Sample size

A

A sample of at least 50-100 participants per group (treatment and placebo) is a starting point.

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2
Q

Specific criteria for female participants

A
  • Females with documented LOW LH levels
  • Women ages between 25-40 years old (optimal fertility age)
  • EXCLUDE participants with other known infertility issues
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3
Q

Independent variable

A

Administration of recombinant LH (yes vs. no/placebo)

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4
Q

Dependent variable

A

Success of ovulation

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5
Q

Controlled variables

A
  • Age of participants
  • Time of LH administration
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6
Q

How would they administer the treatment?

A

Recombinant LH would be administered via subcutaneous injection.

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7
Q

How much?

A

Typical doses range from 75 IU to 150 IU per injection, depending on the severity of LH deficiency.

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8
Q

How often?

A

Daily injections during the mid-to-late follicular phase (usually days 7-12 of the cycle).

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9
Q

Duration of the study

A

3-6 months per participant, allowing for several ovulation attempts

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10
Q

Placebo and its function

A

An injection that looks identical to the LH injection but contains no active ingredient. Its function is to serve as a control to compare the effectiveness of the recombinant LH.

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11
Q

“Chance of ovulation”

A

The probability that ovulation will occur in a given cycle

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12
Q

How is chance of ovulation measured

A
  • Blood tests measuring progesterone levels (elevated levels confirm ovulation).
  • Ultrasound to visualize the rupture of the ovarian follicle.
  • Urinary LH kits might be used to confirm the LH surge that precedes ovulation.
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13
Q

Other factors affecting ovulation

A
  • Lifestyle factors like diet, smoking etc
  • Other medications or treatments participants may be taking
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14
Q

Minimization strategies

A

Provide diet plans, or exclude participants that undergo heavy drug use or smoking etc

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